{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T08:04:33Z","timestamp":1789545873150,"version":"build-2803163510"},"reference-count":8,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p><jats:italic>Objective<\/jats:italic>. Can polymer-based immunohistochemical staining of<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mrow><mml:msup><mml:mrow><mml:mtext>p57<\/mml:mtext><\/mml:mrow><mml:mrow><mml:mtext>kip2<\/mml:mtext><\/mml:mrow><\/mml:msup><\/mml:mrow><\/mml:math>replace DNA analysis as an inexpensive means of differentiating complete mole from partial mole or hydropic abortion?<jats:italic>Methods and Materials<\/jats:italic>. Original paraffin-embedded tissue blocks from 14 equivocal cases were turned over to our laboratory and examined by immunohistochemical staining of<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mrow><mml:msup><mml:mrow><mml:mtext>p57<\/mml:mtext><\/mml:mrow><mml:mrow><mml:mtext>kip2<\/mml:mtext><\/mml:mrow><\/mml:msup><\/mml:mrow><\/mml:math>.<jats:italic>Results<\/jats:italic>. Four of the 14 cases showed clearly negative nuclear staining in cytotrophoblasts and villous stromal cells: these results were fully concordant with the control staining. The remaining 10 cases showed apparently positive staining in cytotrophoblasts and villous stromal cells. Without DNA analysis we are able to clearly differentiate the 4 cases of complete mole among the 14 equivocal cases. During follow-up, secondary low-risk gestational trophoblastic neoplasia (GTN) developed in 1 of the 4 cases of complete mole: the GTN was treated by single-agent chemotherapy. No subsequent changes were observed during follow-up in the other cases.<jats:italic>Conclusion<\/jats:italic>. Polymer-based immunohistochemical staining of<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mrow><mml:msup><mml:mrow><mml:mtext>p57<\/mml:mtext><\/mml:mrow><mml:mrow><mml:mtext>kip2<\/mml:mtext><\/mml:mrow><\/mml:msup><\/mml:mrow><\/mml:math>(paternally imprinted gene, expressed from maternal allele) is a very effective method that can be used to differentiate androgenetic complete mole from partial mole and hydropic abortion. We might be able to avoid the cost of DNA analysis.<\/jats:p>","DOI":"10.1155\/2015\/905648","type":"journal-article","created":{"date-parts":[[2015,6,16]],"date-time":"2015-06-16T21:04:10Z","timestamp":1434488650000},"page":"1-5","source":"Crossref","is-referenced-by-count":9,"title":["Clinical Usefulness of Immunohistochemical Staining of p57<sup>kip2<\/sup>for the Differential Diagnosis of Complete Mole"],"prefix":"10.1155","volume":"2015","author":[{"given":"Shigeru","family":"Sasaki","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Iino Hospital, 4-3-2 Fuda, Ch\u014dfu, Tokyo 182-0024, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasushi","family":"Sasaki","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Showa University Northern Yokohama Hospital and Showa University School of Medicine, 35-1 Chigasaki Chuo, Tsuduki-Ku, Yokohama, Kanagawa 224-8503, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiaki","family":"Kunimura","sequence":"additional","affiliation":[{"name":"Department of Pathology, Showa University School of Medicine and Showa University Northern Yokohama Hospital, 35-1 Chigasaki Chuo, Tsuduki-Ku, Yokohama, Kanagawa 224-8503, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihiko","family":"Sekizawa","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Showa University Northern Yokohama Hospital and Showa University School of Medicine, 35-1 Chigasaki Chuo, Tsuduki-Ku, Yokohama, Kanagawa 224-8503, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihiro","family":"Kojima","sequence":"additional","affiliation":[{"name":"Maternity Clinic Kojima, 4-1-27 Asahi-Cho, Akishima, Tokyo 196-0025, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichi","family":"Iino","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Iino Hospital, 4-3-2 Fuda, Ch\u014dfu, Tokyo 182-0024, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"98","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/S0143-4004(03)00130-9"},{"issue":"3","key":"2","first-page":"269","volume":"78","year":"1998","journal-title":"Laboratory Investigation"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200110000-00001"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/11.26.3267"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1053\/hupa.2002.129421"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2559.2003.01667.x"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2559.2003.01716.x"},{"issue":"5","key":"8","first-page":"307","volume":"50","year":"2005","journal-title":"The Journal of Reproductive Medicine"}],"container-title":["BioMed Research International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2015\/905648.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2015\/905648.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2015\/905648.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2016,8,19]],"date-time":"2016-08-19T04:03:14Z","timestamp":1471579394000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/bmri\/2015\/905648\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":8,"alternative-id":["905648","905648"],"URL":"https:\/\/doi.org\/10.1155\/2015\/905648","relation":{},"ISSN":["2314-6133","2314-6141"],"issn-type":[{"value":"2314-6133","type":"print"},{"value":"2314-6141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015]]}}}