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Accordingly, high levels of D-Asp in knockout mice for<jats:italic>Ddo<\/jats:italic>gene (<jats:italic>Ddo<\/jats:italic><jats:sup>\u2212\/\u2212<\/jats:sup>) or in mice treated with D-Asp increase NMDAR-dependent processes. We have here evaluated in<jats:italic>Ddo<\/jats:italic><jats:sup>\u2212\/\u2212<\/jats:sup>mice the effect of high levels of free D-Asp on the long-term plastic changes along the nociceptive pathway occurring in chronic and acute pain condition. We found that<jats:italic>Ddo<\/jats:italic><jats:sup>\u2212\/\u2212<\/jats:sup>mice show an increased evoked activity of the nociceptive specific (NS) neurons of the dorsal horn of the spinal cord (L4\u2013L6) and a significant decrease of mechanical and thermal thresholds, as compared to control mice. Moreover,<jats:italic>Ddo<\/jats:italic>gene deletion exacerbated the nocifensive responses in the formalin test and slightly reduced pain thresholds in neuropathic mice up to 7 days after chronic constriction injury. These findings suggest that the NMDAR agonist, D-Asp, may play a role in the regulation of NS neuron electrophysiological activity and behavioral responses in physiological and pathological pain conditions.<\/jats:p>","DOI":"10.1155\/2015\/905906","type":"journal-article","created":{"date-parts":[[2015,1,5]],"date-time":"2015-01-05T16:47:56Z","timestamp":1420476476000},"page":"1-10","source":"Crossref","is-referenced-by-count":31,"title":["D-Aspartate Modulates Nociceptive-Specific Neuron Activity and Pain Threshold in Inflammatory and Neuropathic Pain Condition in Mice"],"prefix":"10.1155","volume":"2015","author":[{"given":"Serena","family":"Boccella","sequence":"first","affiliation":[{"name":"Pharmacology Division, Department of Experimental Medicine, The Second University of Naples, Via Costantinopoli 16, 80138 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Vacca","sequence":"additional","affiliation":[{"name":"CNR, National Research Council, Cell Biology and Neurobiology Institute, Roma, Italy"},{"name":"IRCCS, Santa Lucia Foundation, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Errico","sequence":"additional","affiliation":[{"name":"Laboratory of Behavioural Neuroscience, Ceinge Biotecnologie Avanzate, Via G. 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