{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T15:17:10Z","timestamp":1791213430361,"version":"4.1.0"},"reference-count":57,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,8,27]],"date-time":"2015-08-27T00:00:00Z","timestamp":1440633600000},"content-version":"vor","delay-in-days":238,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Rheumatology"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. Familial Mediterranean fever (FMF) is a periodic AR autoinflammatory disorder. This comprehensive study describes FMF in Iran as a country near Mediterranean area. <jats:italic>Materials and Methods<\/jats:italic>. From the country FMF registration center 403 patients according to Tel\u2010Hashomer criteria enrolled this study, 239 patients had MEFV gene mutations analyses. Data, if needed, was analyzed by SPSS v20. <jats:italic>Results<\/jats:italic>. 175 patients (43.4%) were female and 228 patients (56.6%) were male. The mean age was 21.3 years. Abdominal pain was in 93.3% patients and 88.1% had fever. Abdominal pain was the main complaint of patients in (49.6%). The mean interval between attacks was 36.5 \u00b1 29.6 days and the mean duration of every episodes was 43.3 \u00b1 34.5 hours. 15.1% of patients had positive family history and 12.7% had previous surgery; in 52.3% of patients delay in diagnosis was more than three years. 12 common MEFV gene mutations were analyzed, 21.33% were without mutations, 39.7% had compound heterozygote, 25.52% showed heterozygous, and 13.38% showed homozygous results. The most common compound genotype was M694V\u2010V726A (% 10.46) and in alleles M694V (% 20.9) and V726A (% 12.7) were the most frequent mutations, respectively. <jats:italic>Conclusion<\/jats:italic>. M694V was the most common mutation, and the most common compound genotype was M694V\u2010V726A. Our genotype results are similar to Arabs and in some way to Armenians, erysipelas\u2010like skin lesions are not common in this area, and clinical criteria are the preferred methods in diagnosis of FMF.<\/jats:p>","DOI":"10.1155\/2015\/912137","type":"journal-article","created":{"date-parts":[[2015,8,27]],"date-time":"2015-08-27T21:35:08Z","timestamp":1440711308000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Familial Mediterranean Fever in Iran: A Report from FMF Registration Center"],"prefix":"10.1155","volume":"2015","author":[{"given":"Farhad","family":"Salehzadeh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,8,27]]},"reference":[{"key":"e_1_2_7_1_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2350-5-4"},{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/gim.0b013e3182060456"},{"key":"e_1_2_7_3_2","first-page":"261","article-title":"Familial Mediterranean Fever (FMF): from diagnosis to treatment","volume":"14","author":"Medlej-Hashim M.","year":"2004","journal-title":"Sant\u00e9"},{"key":"e_1_2_7_4_2","first-page":"143","article-title":"Autoinflammatory disorders: a new concept in hereditary periodic fever syndromes","volume":"21","author":"Rubio M. 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