{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T23:47:16Z","timestamp":1790812036971,"version":"4.1.0"},"reference-count":42,"publisher":"Wiley","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2015]]},"abstract":"\n Objective.<\/jats:italic>\n Functional dyspepsia (FD) is a frequent clinical finding in western world. The aim of this study is to compare the efficacy of a ginger and artichoke supplementation versus placebo in the treatment of FD.\n Methods.<\/jats:italic>\n A prospective multicentre, double blind, randomized, placebo controlled, parallel-group comparison of the supplement and placebo over a period of 4 weeks was performed. Two capsules\/day were supplied (before lunch and dinner) to 126 FD patients (supplementation\/placebo: 65\/61).\n Results<\/jats:italic>\n . After 14 days of treatment, only supplementation group (SG) showed a significant amelioration (SG:\n \n \n \n \u03b1<\/mml:mi>\n <\/mml:mrow>\n \n S<\/mml:mtext>\n <\/mml:mrow>\n <\/mml:msub>\n =<\/mml:mo>\n +<\/mml:mo>\n 1.195<\/mml:mn>\n <\/mml:math>\n MCA score units (u),\n \n P<\/mml:mi>\n =<\/mml:mo>\n 0.017<\/mml:mn>\n <\/mml:math>\n ; placebo:\n \n \n \n \u03b1<\/mml:mi>\n <\/mml:mrow>\n \n P<\/mml:mtext>\n <\/mml:mrow>\n <\/mml:msub>\n =<\/mml:mo>\n +<\/mml:mo>\n 0.347<\/mml:mn>\n <\/mml:math>\n \u2009u,\n \n P<\/mml:mi>\n =<\/mml:mo>\n 0.513<\/mml:mn>\n <\/mml:math>\n ). The intercept (\n \n \n \u03b1<\/mml:mi>\n <\/mml:mrow>\n <\/mml:math>\n ) resulted to be significantly higher in SG than in placebo (\n \n \n \n \u03b1<\/mml:mi>\n <\/mml:mrow>\n \n S<\/mml:mtext>\n <\/mml:mrow>\n <\/mml:msub>\n -<\/mml:mo>\n \n \n \u03b1<\/mml:mi>\n <\/mml:mrow>\n \n P<\/mml:mtext>\n <\/mml:mrow>\n <\/mml:msub>\n =<\/mml:mo>\n +<\/mml:mo>\n 0.848<\/mml:mn>\n <\/mml:math>\n \u2009u,\n \n P<\/mml:mi>\n <<\/mml:mo>\n 0.001<\/mml:mn>\n <\/mml:math>\n ). At the end of the study, the advantage of SG versus placebo persists without variation (\n \n \n \n \u03b2<\/mml:mi>\n <\/mml:mrow>\n \n S<\/mml:mtext>\n <\/mml:mrow>\n <\/mml:msub>\n -<\/mml:mo>\n \n \n \u03b2<\/mml:mi>\n <\/mml:mrow>\n \n P<\/mml:mtext>\n <\/mml:mrow>\n <\/mml:msub>\n =<\/mml:mo>\n +<\/mml:mo>\n 0.077<\/mml:mn>\n <\/mml:math>\n \u2009u,\n \n P<\/mml:mi>\n =<\/mml:mo>\n 0.542<\/mml:mn>\n <\/mml:math>\n ). In SG, a significant advantage is observed for nausea (\n \n \n \n \u03b2<\/mml:mi>\n <\/mml:mrow>\n \n S<\/mml:mtext>\n <\/mml:mrow>\n <\/mml:msub>\n -<\/mml:mo>\n \n \n \u03b2<\/mml:mi>\n <\/mml:mrow>\n \n P<\/mml:mtext>\n <\/mml:mrow>\n <\/mml:msub>\n =<\/mml:mo>\n -<\/mml:mo>\n 0.398<\/mml:mn>\n <\/mml:math>\n \u2009u,\n \n P<\/mml:mi>\n <<\/mml:mo>\n 0.001<\/mml:mn>\n <\/mml:math>\n ), epigastric fullness (\n \n \n \n \u03b2<\/mml:mi>\n <\/mml:mrow>\n \n S<\/mml:mtext>\n <\/mml:mrow>\n <\/mml:msub>\n -<\/mml:mo>\n \n \n \u03b2<\/mml:mi>\n <\/mml:mrow>\n \n P<\/mml:mtext>\n <\/mml:mrow>\n <\/mml:msub>\n =<\/mml:mo>\n -<\/mml:mo>\n 0.241<\/mml:mn>\n <\/mml:math>\n ,\n \n P<\/mml:mi>\n <<\/mml:mo>\n 0.001<\/mml:mn>\n <\/mml:math>\n ), epigastric pain (\n \n \n \n \u03b2<\/mml:mi>\n <\/mml:mrow>\n \n S<\/mml:mtext>\n <\/mml:mrow>\n <\/mml:msub>\n -<\/mml:mo>\n \n \n \u03b2<\/mml:mi>\n <\/mml:mrow>\n \n P<\/mml:mtext>\n <\/mml:mrow>\n <\/mml:msub>\n =<\/mml:mo>\n -<\/mml:mo>\n 0.173<\/mml:mn>\n <\/mml:math>\n \u2009u,\n \n P<\/mml:mi>\n =<\/mml:mo>\n 0.002<\/mml:mn>\n <\/mml:math>\n ), and bloating (\n \n \n \n \u03b2<\/mml:mi>\n <\/mml:mrow>\n \n S<\/mml:mtext>\n <\/mml:mrow>\n <\/mml:msub>\n -<\/mml:mo>\n \n \n \u03b2<\/mml:mi>\n <\/mml:mrow>\n \n P<\/mml:mtext>\n <\/mml:mrow>\n <\/mml:msub>\n =<\/mml:mo>\n -<\/mml:mo>\n 0.167<\/mml:mn>\n <\/mml:math>\n \u2009u,\n \n P<\/mml:mi>\n =<\/mml:mo>\n 0.017<\/mml:mn>\n <\/mml:math>\n ).\n Conclusions<\/jats:italic>\n . The association between ginger and artichoke leaf extracts appears safe and efficacious in the treatment of FD and could represent a promising treatment for this disease.\n <\/jats:p>","DOI":"10.1155\/2015\/915087","type":"journal-article","created":{"date-parts":[[2015,4,14]],"date-time":"2015-04-14T17:05:02Z","timestamp":1429031102000},"page":"1-9","source":"Crossref","is-referenced-by-count":66,"title":["The Effect of Ginger (\n Zingiber officinalis<\/i>\n ) and Artichoke (\n Cynara cardunculus<\/i>\n ) Extract Supplementation on Functional Dyspepsia: A Randomised, Double-Blind, and Placebo-Controlled Clinical Trial"],"prefix":"10.1155","volume":"2015","author":[{"given":"Attilio","family":"Giacosa","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Policlinico di Monza, 20900 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davide","family":"Guido","sequence":"additional","affiliation":[{"name":"Section of Biostatistics, Neurophysiology and Psychiatry, Department of Brain and Behavioral Sciences, University of Pavia, 27100 Pavia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Grassi","sequence":"additional","affiliation":[{"name":"Section of Biostatistics, Neurophysiology and Psychiatry, Department of Brain and Behavioral Sciences, University of Pavia, 27100 Pavia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonella","family":"Riva","sequence":"additional","affiliation":[{"name":"Research and Development Unit, Indena, 20139 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Morazzoni","sequence":"additional","affiliation":[{"name":"Research and Development Unit, Indena, 20139 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ezio","family":"Bombardelli","sequence":"additional","affiliation":[{"name":"Research and Development Unit, Indena, 20139 Milan, 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