{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T19:51:48Z","timestamp":1788292308392,"version":"build-2803163510"},"reference-count":43,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Analytical Cellular Pathology"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p>Diffuse large B-cell lymphoma (DLBCL) is the most common type of lymphomas worldwide. The pathogenesis of lymphomas is not yet well understood. SV40 induces malignant transformation by the large T-antigen (L-TAG) and promotes transformation by binding and inactivating p53 and pRb. L-TAG can bind pRb promoting the activation of the E2F1 transcription factor, thus inducing the expression of genes required for the entry to the S phase and leading to cell transformation. This immunohistochemical study was conducted to assess the prognostic role and relationship of SV40 L-TAG and E2F1 in diffuse large B-cell lymphoma (DLBCL) of Egyptian patients. This retrospective study was conducted on 105 tissue specimens including 20 follicular hyperplasia and 85 DLBCL cases. SV40 L-TAG was identified in 3\/85 (4%) of DLBCL. High Ki-67 labeling index (Ki-67 LI) and apoptotic count were associated with high E2F1 expression (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>p<\/mml:mi><mml:mn>&lt;0.001<\/mml:mn><\/mml:math>for all). No significant association was reached between E2F1 and SV40. E2F1 expression proved to be the most and first independent prognostic factor on overall survival of DLBCL patients (HR = 5.79, 95% CI = 2.3\u201314.6, and<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>p<\/mml:mi><mml:mn>&lt;0.001<\/mml:mn><\/mml:math>). Upregulation of E2F1 has been implicated in oncogenesis, prognosis, and prediction of therapeutic response but is not seemingly to have a relationship with the accused SV40.<\/jats:p>","DOI":"10.1155\/2015\/919834","type":"journal-article","created":{"date-parts":[[2015,10,27]],"date-time":"2015-10-27T22:43:06Z","timestamp":1445985786000},"page":"1-12","source":"Crossref","is-referenced-by-count":6,"title":["The Prognostic Role and Relationship between E2F1 and SV40 in Diffuse Large B-Cell Lymphoma of Egyptian Patients"],"prefix":"10.1155","volume":"2015","author":[{"given":"Rehab M.","family":"Samaka","sequence":"first","affiliation":[{"name":"Pathology Department, Faculty of Medicine, Menoufia University, Shebin El-Kom, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hayam A.","family":"Aiad","sequence":"additional","affiliation":[{"name":"Pathology Department, Faculty of Medicine, Menoufia University, Shebin El-Kom, 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