{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T21:03:02Z","timestamp":1740171782324,"version":"3.37.3"},"reference-count":16,"publisher":"Wiley","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100001349","name":"National Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001349","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parkinson's Disease"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p><jats:italic>Objective<\/jats:italic>. COQ2 mutations have been reported in Japanese multiple system atrophy (MSA) patients. We examined the role of COQ2 in patients with dementia and essential tremor (ET), two common neurodegenerative conditions.<jats:italic>Materials &amp; Methods<\/jats:italic>. A total of 2064 subjects, including 560 patients with dementia, 466 patients with ET, and 1038 healthy controls, were included. Genotyping for the COQ2 V393A (T&gt;C) was carried out. Odds ratio (OR) adjusted by age and gender, together with 95% confidence interval (CI), was reported by means of logistic regression.<jats:italic>Results<\/jats:italic>. The frequency of the polymorphic variant V393A heterozygous (T\/C) was 2.7% in dementia, 1.1% in ET, and 2.5% in controls (OR = 0.70, 95% confidence interval is 0.29\u20131.72 for dementia, and OR = 0.47, 95% confidence interval is 0.17\u20131.31,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.1217<\/mml:mn><\/mml:math>for ET). There was no significant association between V393A variant with dementia and ET.<jats:italic>Conclusion<\/jats:italic>. There was no significant association between V393A variant with dementia and ET. COQ2 gene is unlikely to play a significant role in patients with dementia or ET in our population.<\/jats:p>","DOI":"10.1155\/2015\/926280","type":"journal-article","created":{"date-parts":[[2015,4,22]],"date-time":"2015-04-22T17:03:36Z","timestamp":1429722216000},"page":"1-4","source":"Crossref","is-referenced-by-count":1,"title":["Association Analysis of COQ2 Variant in Dementia and Essential Tremor"],"prefix":"10.1155","volume":"2015","author":[{"given":"Yin Xia","family":"Chao","sequence":"first","affiliation":[{"name":"Department of Neurology, Singapore General Hospital, Singapore 169608"},{"name":"National Neuroscience Institute, Singapore 308433"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ebonne Yu Lin","family":"Ng","sequence":"additional","affiliation":[{"name":"Department of Neurology, Singapore General Hospital, Singapore 169608"},{"name":"National Neuroscience Institute, Singapore 308433"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huihua","family":"Li","sequence":"additional","affiliation":[{"name":"Duke-NUS Graduate Medical School, Singapore 169857"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kandiah","family":"Nagaendran","sequence":"additional","affiliation":[{"name":"National Neuroscience Institute, Singapore 308433"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuen","family":"Yih","sequence":"additional","affiliation":[{"name":"Health Assessment Centre, Singapore General Hospital, Singapore 169608"},{"name":"Health Services Research, Singapore General Hospital, Singapore 169608"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mei Sian","family":"Chong","sequence":"additional","affiliation":[{"name":"Institute of Geriatrics and Active Ageing, Tan Tock Seng Hospital, Singapore 308433"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kumar M.","family":"Prakash","sequence":"additional","affiliation":[{"name":"Department of Neurology, Singapore General Hospital, Singapore 169608"},{"name":"National Neuroscience Institute, Singapore 308433"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louis","family":"Tan","sequence":"additional","affiliation":[{"name":"National Neuroscience Institute, Singapore 308433"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wing Lok","family":"Au","sequence":"additional","affiliation":[{"name":"National Neuroscience Institute, Singapore 308433"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Clinical Research, Singapore General Hospital, Singapore 169608"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhi Dong","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Neurology, Singapore General Hospital, Singapore 169608"},{"name":"National Neuroscience Institute, Singapore 308433"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Murni","family":"Tio","sequence":"additional","affiliation":[{"name":"Department of Neurology, Singapore General Hospital, Singapore 169608"},{"name":"National Neuroscience Institute, Singapore 308433"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ratnagopal","family":"Pavanni","sequence":"additional","affiliation":[{"name":"Department of Neurology, Singapore General Hospital, Singapore 169608"},{"name":"National Neuroscience Institute, Singapore 308433"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eng King","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Neurology, Singapore General Hospital, Singapore 169608"},{"name":"National Neuroscience Institute, Singapore 308433"},{"name":"Duke-NUS Graduate Medical School, Singapore 169857"},{"name":"Department of Clinical Research, Singapore General Hospital, Singapore 169608"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1223812"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.2174\/18715273113129990071"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1086\/500092"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1212115"},{"issue":"3","key":"13","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1002\/mds.26138","volume":"30","year":"2015","journal-title":"Movement Disorders"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2014.08.006"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2014.09.010"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-015-2083-7"},{"year":"1994","key":"5"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1212\/wnl.34.7.939"},{"key":"7","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1002\/mds.870130104","volume":"13","year":"1998","journal-title":"Movement Disorders"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20040261"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2013.01.004"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamem.2003.11.012"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.2174\/156720205774962656"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1007\/s10545-014-9749-9"}],"container-title":["Parkinson's Disease"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/pd\/2015\/926280.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/pd\/2015\/926280.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/pd\/2015\/926280.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,23]],"date-time":"2017-06-23T06:02:55Z","timestamp":1498197775000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/pd\/2015\/926280\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":16,"alternative-id":["926280","926280"],"URL":"https:\/\/doi.org\/10.1155\/2015\/926280","relation":{},"ISSN":["2090-8083","2042-0080"],"issn-type":[{"type":"print","value":"2090-8083"},{"type":"electronic","value":"2042-0080"}],"subject":[],"published":{"date-parts":[[2015]]}}}