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The crude ethanolic-extract, including organic and aqueous fractions, were tested for cytotoxicity on HepG2 and HepG2.2.15 cells (IC<jats:sub>50<\/jats:sub>= 684\u2009<jats:italic>\u03bc<\/jats:italic>g\/mL). Of these, the ethyl acetate and aqueous fractions showed the most promising, dose-dependent hepatoprotection in DCFH-toxicated cells at 48\u2009h. In CCl<jats:sub>4<\/jats:sub>-injured rats, oral administration of<jats:italic>AM<\/jats:italic>ethanol extract (250 and 500\u2009mg\/kg\u00b7bw) for three weeks significantly normalized the sera aminotransferases, alkaline phosphatase, bilirubin, cholesterol, triglycerides, and lipoprotein levels and elevated tissue nonprotein sulphydryl and total protein. The histopathology of dissected livers also revealed that<jats:italic>AM<\/jats:italic>cured the tissue lesions. The phytochemical screening of the fractions showed presence of alkaloids, flavonoids, tannins, sterols, and saponins. Further, anti-HBV potential of the fractions was evaluated on HepG2.2.15 cells. Of these, the n-butanol and aqueous fractions exhibited the best inhibitory effects on HBsAg and HBeAg expressions in dose- and time-dependent manner. Taken together, while the ethyl acetate and aqueous fractions exhibited the most promising antioxidant\/hepatoprotective and anti-HBV activity, respectively, the n-butanol partition showed both activities. Therefore, the therapeutic potential of<jats:italic>AM<\/jats:italic>extracts warrants further isolation of the active principle(s) and its phytochemical as well as biological studies.<\/jats:p>","DOI":"10.1155\/2015\/929131","type":"journal-article","created":{"date-parts":[[2015,4,9]],"date-time":"2015-04-09T21:02:40Z","timestamp":1428613360000},"page":"1-10","source":"Crossref","is-referenced-by-count":25,"title":["Hepatoprotective and Antiviral Efficacy of<i>Acacia mellifera<\/i>Leaves Fractions against Hepatitis B Virus"],"prefix":"10.1155","volume":"2015","author":[{"given":"Ahmed H.","family":"Arbab","sequence":"first","affiliation":[{"name":"Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia"},{"name":"Department of Pharmacognosy, College of Pharmacy, Omdurman Islamic University, Khartoum 14415, Sudan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad 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