{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T02:22:00Z","timestamp":1789698120801,"version":"4.0.1"},"reference-count":46,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p><jats:italic>Background.<\/jats:italic>We investigated a novel technique, intraoperative<jats:sup>99\u2009<jats:roman>m<\/jats:roman><\/jats:sup>Tc-Sestamibi (MIBI) imaging (neck and excised specimen (ES)), using a large field-of-view portable gamma camera (LFOVGC), for expediting confirmation of MIBI-avid parathyroid adenoma removal.<jats:italic>Methods.<\/jats:italic>Twenty patients with MIBI-avid parathyroid adenomas were preoperatively administered MIBI and intraoperatively imaged prior to incision (neck) and immediately following resection (neck and\/or ES). Preoperative and intraoperative serum parathyroid hormone monitoring (IOPTH) and pathology (path) were also performed.<jats:italic>Results.<\/jats:italic>MIBI neck activity was absent and specimen activity was present in 13\/20 with imaging after initial ES removal. In the remaining 7\/20 cases, residual neck activity and\/or absent ES activity prompted excision of additional tissue, ultimately leading to complete hyperfunctioning tissue excision. Postexcision LFOVGC ES imaging confirmed parathyroid adenoma resection 100% when postresection imaging qualitatively had activity (ES) and\/or no activity (neck). The mean \u00b1 SEM time saving using intraoperative LFOVGC data to confirm resection versus first IOPTH or path result would have been 22.0 \u00b1 2 minutes (specimen imaging) and 26.0 \u00b1 3 minutes (neck imaging).<jats:italic>Conclusion.<\/jats:italic>Utilization of a novel real-time intraoperative LFOVGC imaging approach can provide confirmation of MIBI-avid parathyroid adenoma removal appreciably faster than IOPTH and\/or path and may provide a valuable adjunct to parathyroid surgery.<\/jats:p>","DOI":"10.1155\/2015\/930575","type":"journal-article","created":{"date-parts":[[2015,1,12]],"date-time":"2015-01-12T09:38:21Z","timestamp":1421055501000},"page":"1-10","source":"Crossref","is-referenced-by-count":9,"title":["Intraoperative Scintigraphy Using a Large Field-of-View Portable Gamma Camera for Primary Hyperparathyroidism: Initial Experience"],"prefix":"10.1155","volume":"2015","author":[{"given":"Nathan 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