{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T06:55:07Z","timestamp":1773298507274,"version":"3.50.1"},"reference-count":58,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Balance Pharmaceuticals, Inc."}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. This randomized, multicenter, open-label clinical trial was intended to generate pilot data on the efficacy and safety of the gonadotropin-releasing hormone agonist (GnRHa) deslorelin (D) with low-dose estradiol \u00b1 testosterone (E<jats:sub>2<\/jats:sub>\u2009\u2009\u00b1 T) add-back for endometriosis-related pelvic pain.<jats:italic>Methods<\/jats:italic>. Women with pelvic pain and laparoscopically confirmed endometriosis were treated with a six-month course of daily intranasal D with concurrent administration of either transdermal E<jats:sub>2<\/jats:sub>, intranasal E<jats:sub>2<\/jats:sub>, or intranasal E<jats:sub>2<\/jats:sub>\u2009\u2009+ T. Efficacy data included evaluation of dyspareunia, dysmenorrhea, pelvic pain, tenderness, and induration. Cognition and quality of life were also assessed. Safety parameters included assessment of endometrial hyperplasia, bone mineral density (BMD), and hot flashes.<jats:italic>Results<\/jats:italic>. Endometriosis symptoms and signs scores decreased in all treatment arms from a baseline average of 7.4 to 2.5 after 3 months of treatment and 3.4 after 6 months. BMD changes and incidence of hot flashes were minimal, and no endometrial hyperplasia was observed. Patient-reported outcomes showed significant improvement across multiple domains.<jats:italic>Conclusions<\/jats:italic>. Daily intranasal D with low dose E<jats:sub>2<\/jats:sub>\u2009\u2009\u00b1 T add-back resulted in significant reduction in severity of endometriosis symptoms and signs with few safety signals and minimal hypoestrogenic symptoms that would be expected with the use of a GnRHa alone.<\/jats:p>","DOI":"10.1155\/2015\/934164","type":"journal-article","created":{"date-parts":[[2015,12,31]],"date-time":"2015-12-31T21:46:56Z","timestamp":1451598416000},"page":"1-9","source":"Crossref","is-referenced-by-count":20,"title":["Treatment of Endometriosis with the GnRHa Deslorelin and Add-Back Estradiol and Supplementary Testosterone"],"prefix":"10.1155","volume":"2015","author":[{"given":"Sanjay K.","family":"Agarwal","sequence":"first","affiliation":[{"name":"Center for Endometriosis Research and Treatment, Department of Reproductive Medicine, UC San Diego, 9500 Gilman Drive, No. 0633, La Jolla, CA 92093-0633, 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