{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T11:02:36Z","timestamp":1789642956805,"version":"4.0.0"},"reference-count":9,"publisher":"Wiley","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Pediatrics"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p>We report the case of 17-year-old female diagnosed with Costello syndrome. Genetic testing provided a proof with G12S mutation in the HRAS gene since 3 years of age with a presentation of severe nodulocystic acne on her face. After 2 months of oral isotretinoin treatment, improvement in her acne was observed. Interestingly, an unexpected significant improvement of acanthosis nigricans on her neck and dorsum of her hands was found as well. We present this case as a successful treatment option by using oral isotretinoin for the treatment of acanthosis nigricans in Costello syndrome patients.<\/jats:p>","DOI":"10.1155\/2015\/934865","type":"journal-article","created":{"date-parts":[[2015,2,28]],"date-time":"2015-02-28T21:01:01Z","timestamp":1425157261000},"page":"1-4","source":"Crossref","is-referenced-by-count":5,"title":["Costello Syndrome with Severe Nodulocystic Acne: Unexpected Significant Improvement of Acanthosis Nigricans after Oral Isotretinoin Treatment"],"prefix":"10.1155","volume":"2015","author":[{"given":"Leelawadee","family":"Sriboonnark","sequence":"first","affiliation":[{"name":"Division of Dermatology, Department of Pediatrics, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harleen","family":"Arora","sequence":"additional","affiliation":[{"name":"Miller School of Medicine, Department of Pediatric Dermatology, University of Miami, 1600 NW 10th Avenue, Rosenstiel Medical Science Building, Room 2023, Miami, FL 33136, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leyre","family":"Falto-Aizpurua","sequence":"additional","affiliation":[{"name":"Miller School of Medicine, Department of Pediatric Dermatology, University of Miami, 1600 NW 10th Avenue, Rosenstiel Medical Science Building, Room 2023, Miami, FL 33136, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonal","family":"Choudhary","sequence":"additional","affiliation":[{"name":"Miller School of Medicine, Department of Pediatric Dermatology, University of Miami, 1600 NW 10th Avenue, Rosenstiel Medical Science Building, Room 2023, Miami, FL 33136, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth Alvarez","family":"Connelly","sequence":"additional","affiliation":[{"name":"Miller School of Medicine, Department of Pediatric Dermatology, University of Miami, 1600 NW 10th Avenue, Rosenstiel Medical Science Building, Room 2023, Miami, FL 33136, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","volume-title":"Costello syndrome","year":"1993"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1111\/pde.12171"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2007.02920.x"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2011.10744.x"},{"issue":"2","key":"5","first-page":"114","volume":"13","year":"1977","journal-title":"Australian Paediatric Journal"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.2005.040352"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.127.8.1139"},{"issue":"2","key":"8","doi-asserted-by":"crossref","first-page":"173","DOI":"10.2340\/0001555566173174","volume":"66","year":"1986","journal-title":"Acta Dermato-Venereologica"},{"issue":"6","key":"9","first-page":"677","volume":"2","year":"2003","journal-title":"Journal of Drugs in Dermatology"}],"container-title":["Case Reports in Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/cripe\/2015\/934865.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/cripe\/2015\/934865.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/cripe\/2015\/934865.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,20]],"date-time":"2025-05-20T15:23:37Z","timestamp":1747754617000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/cripe\/2015\/934865\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":9,"alternative-id":["934865","934865"],"URL":"https:\/\/doi.org\/10.1155\/2015\/934865","relation":{},"ISSN":["2090-6803","2090-6811"],"issn-type":[{"value":"2090-6803","type":"print"},{"value":"2090-6811","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015]]}}}