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Contrastively, mesenchymal-to-epithelial transition (MET) of HSCs facilitates the fibrosis resolution. Here we investigated the effect of Fuzheng Huayu (FZHY) recipe, a Chinese herbal decoction made of<jats:italic>Radix Salviae Miltiorrhizae<\/jats:italic>,<jats:italic>Semen Persicae<\/jats:italic>,<jats:italic>Cordyceps sinensis<\/jats:italic>,<jats:italic>Pollen Pini<\/jats:italic>, and<jats:italic>Gynostemma pentaphyllum<\/jats:italic>, on liver fibrosis concerning the balance of EMT and MET in HSCs. In contrast to the increased TGF-<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mrow><mml:msub><mml:mrow><mml:mi>\u03b2<\/mml:mi><\/mml:mrow><mml:mrow><mml:mn fontstyle=\"italic\">1<\/mml:mn><\/mml:mrow><\/mml:msub><\/mml:mrow><\/mml:math>\/BMP-7 ratio in activated HSCs, FZHY administration induced significant upregulation of BMP-7 and downregulation of TGF-<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mrow><mml:msub><mml:mrow><mml:mi>\u03b2<\/mml:mi><\/mml:mrow><mml:mrow><mml:mn fontstyle=\"italic\">1<\/mml:mn><\/mml:mrow><\/mml:msub><\/mml:mrow><\/mml:math>at both transcription and translation levels. Restoration of TGF-<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mrow><mml:msub><mml:mrow><mml:mi>\u03b2<\/mml:mi><\/mml:mrow><mml:mrow><mml:mn fontstyle=\"italic\">1<\/mml:mn><\/mml:mrow><\/mml:msub><\/mml:mrow><\/mml:math>\/BMP-7 ratio inhibited the expression of p38 MAPK and phosphorylated p38 MAPK, resulting in the reversal of epithelial-to-mesenchymal transition (EMT) to mesenchymal-to-epithelial transition (MET) as characterized by the abolishment of EMT markers (<jats:italic>\u03b1<\/jats:italic>-SMA and desmin) and reoccurrence of MET marker (E-cadherin).<jats:italic>In vivo<\/jats:italic>treatment of FZHY recipe also demonstrated the statistical reduction of activated HSCs with EMT phenotype, which attenuated the carbon tetrachloride- (CCl<jats:sub>4<\/jats:sub>-) induced liver fibrosis in a dose-dependent manner. These findings may highlight a novel antifibrotic role of FZHY recipe on the basis of rebalancing EMT and MET in HSCs.<\/jats:p>","DOI":"10.1155\/2015\/935903","type":"journal-article","created":{"date-parts":[[2015,12,31]],"date-time":"2015-12-31T16:05:47Z","timestamp":1451577947000},"page":"1-11","source":"Crossref","is-referenced-by-count":18,"title":["Fuzheng Huayu Recipe Ameliorates Liver Fibrosis by Restoring Balance between Epithelial-to-Mesenchymal Transition and Mesenchymal-to-Epithelial Transition in Hepatic Stellate Cells"],"prefix":"10.1155","volume":"2015","author":[{"given":"Qin","family":"Pan","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200092, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Qin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Xinhua Hospital, Shanghai Jiaotong University 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