{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,10,11]],"date-time":"2022-10-11T11:10:51Z","timestamp":1665486651194},"reference-count":24,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"name":"Foundation of Sichuan Provincial Health Department","award":["110480","120569","2011YG-A15"],"award-info":[{"award-number":["110480","120569","2011YG-A15"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p>Between June 2010 and June 2011, 176 patients were divided into 2 groups: a group with spinal metastasis of solid tumors (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>n<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>157<\/mml:mn><\/mml:math>) and a group with multiple myeloma (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>n<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>19<\/mml:mn><\/mml:math>). Both groups were further divided into 2 subgroups: a group receiving zoledronic acid before surgery and a control group. The zoledronic acid subgroup of the solid tumors group was group A (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>n<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>81<\/mml:mn><\/mml:math>), the control subgroup of the solid tumors group was group B (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mi>n<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>76<\/mml:mn><\/mml:math>), the zoledronic acid subgroup of the multiple myeloma group was group C (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:mi>n<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>10<\/mml:mn><\/mml:math>), and the control subgroup of the multiple myeloma group was group D (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\"><mml:mi>n<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>9<\/mml:mn><\/mml:math>). The average intraoperative blood loss during spinal surgery was as follows:<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M7\"><mml:mn>1311<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn>691<\/mml:mn><\/mml:math>\u2009mL in group A and<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M8\"><mml:mn>1752<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn>740<\/mml:mn><\/mml:math>\u2009mL in group B (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M9\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0<\/mml:mn><mml:mo>.<\/mml:mo><mml:mn>000<\/mml:mn><\/mml:math>) and<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M10\"><mml:mn>1994<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn>810<\/mml:mn><\/mml:math>\u2009mL in group C and<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M11\"><mml:mn>3134<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn>795<\/mml:mn><\/mml:math>\u2009mL in group D (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M12\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0<\/mml:mn><mml:mo>.<\/mml:mo><mml:mn>000<\/mml:mn><\/mml:math>). Patients receiving zoledronic acid before surgery had significantly less intraoperative bleeding than those who did not receive it. Preoperative use of zoledronic acid can effectively reduce intraoperative bleeding during surgery for the treatment of spinal tumors.<\/jats:p>","DOI":"10.1155\/2015\/936307","type":"journal-article","created":{"date-parts":[[2015,1,22]],"date-time":"2015-01-22T16:01:26Z","timestamp":1421942486000},"page":"1-7","source":"Crossref","is-referenced-by-count":1,"title":["Zoledronic Acid May Reduce Intraoperative Bleeding in Spinal Tumors: A Prospective Cohort Study"],"prefix":"10.1155","volume":"2015","author":[{"given":"Juan","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Chengdu Military General Hospital, Chengdu 610083, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Chengdu Military General Hospital, Chengdu 610083, China"},{"name":"Department of Orthopedics, Changzheng Hospital, Second Military Medical University, Shanghai 200003, 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