{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T17:59:48Z","timestamp":1761155988863},"reference-count":34,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p>Sixteen methanolic extracts obtained from thirteen plant species, selected either from ethnobotanical or chemotaxonomical data, were screened for their antileishmanial activity against<jats:italic>Leishmania amazonensis<\/jats:italic>. The cytotoxic activity against normal peritoneal macrophages from normal BALB\/c mice was also determined. Eight extracts had IC<jats:sub>50<\/jats:sub>values ranging from &lt;12.5 to 37.8\u2009<jats:italic>\u00b5<\/jats:italic>g\/mL against promastigotes.<jats:italic>Achillea biebersteinii<\/jats:italic>flower,<jats:italic>Euphorbia helioscopia,<\/jats:italic>and<jats:italic>Solanum incanum<\/jats:italic>leaf extracts showed antileishmanial activities with IC<jats:sub>50<\/jats:sub>between &lt;12.5\u201326.9\u2009<jats:italic>\u00b5<\/jats:italic>g\/mL and acceptable selectivity indices of 8\u20135. The other leishmanicidal plant extracts, with IC<jats:sub>50<\/jats:sub>ranging from 18.0 to 29.5\u2009<jats:italic>\u00b5<\/jats:italic>g\/mL, exhibited low selectivity indices.<\/jats:p>","DOI":"10.1155\/2015\/938747","type":"journal-article","created":{"date-parts":[[2015,8,19]],"date-time":"2015-08-19T21:07:16Z","timestamp":1440018436000},"page":"1-6","source":"Crossref","is-referenced-by-count":15,"title":["Evaluation of Antileishmanial Activity of Albaha Medicinal Plants against<i>Leishmania amazonensis<\/i>"],"prefix":"10.1155","volume":"2015","author":[{"given":"Saeed S.","family":"Al-Sokari","sequence":"first","affiliation":[{"name":"Department of Biology, Faculty of Sciences, Al Baha University, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nasser A. Awadh","family":"Ali","sequence":"additional","affiliation":[{"name":"Pharmacognosy Department, Faculty of Clinical Pharmacy, Al Baha University, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lianet","family":"Monzote","sequence":"additional","affiliation":[{"name":"Departamento de Parasitolog\u00eda, Instituto de Medicina Tropical Pedro Kour\u00ed, La Habana, Cuba"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed A.","family":"Al-Fatimi","sequence":"additional","affiliation":[{"name":"Pharmacognosy Department, Faculty of Pharmacy, Aden University, P.O. Box 5411, Ma\u2019alla, Aden, Yemen"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"98","reference":[{"key":"1","year":"2010"},{"issue":"3","key":"3","first-page":"68","volume":"77","year":"1974","journal-title":"Journal of Tropical Medicine and Hygiene"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1016\/s1995-7645(13)60116-9"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/905639"},{"issue":"2","key":"6","first-page":"157","volume":"3","year":"2013","journal-title":"Journal of Asian Scientific Research"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1016\/j.exppara.2010.10.014"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1007\/s00436-002-0768-3"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.3390\/molecules171011379"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6882-12-49"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.3108"},{"key":"12","year":"2012"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1016\/0022-1759(93)90088-O"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1016\/j.parint.2005.01.001"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1128\/aac.45.5.1349-1354.2001"},{"issue":"5","key":"16","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1128\/AAC.43.5.1234","volume":"43","year":"1999","journal-title":"Antimicrobial Agents and Chemotherapy"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1179\/136485910x12786389891281"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.3390\/molecules19056428"},{"issue":"1","key":"19","first-page":"78","volume":"3","year":"2012","journal-title":"International Journal of Phytopharmacology"},{"key":"20","year":"1996"},{"issue":"1","key":"21","first-page":"7","volume":"1","year":"2012","journal-title":"World Journal of Public Health Sciences"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.2334"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.5560\/znc.2011.66c0360"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1016\/j.exppara.2013.03.023"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2007.08.007"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/265025"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.201200063"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2012.05.025"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.3390\/molecules171214349"},{"issue":"4","key":"30","first-page":"167","volume":"77","year":"2012","journal-title":"Agriculturae Conspectus Scientificus"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1080\/14786410600942025"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-8741(03)00269-1"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cdd.4402002"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1179\/136485909X440827"},{"issue":"4","key":"35","first-page":"27","volume":"1","year":"2014","journal-title":"Research Journal of Pharmacognosy"}],"container-title":["BioMed Research International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2015\/938747.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2015\/938747.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2015\/938747.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,29]],"date-time":"2019-08-29T16:03:31Z","timestamp":1567094611000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/bmri\/2015\/938747\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":34,"alternative-id":["938747","938747"],"URL":"https:\/\/doi.org\/10.1155\/2015\/938747","relation":{},"ISSN":["2314-6133","2314-6141"],"issn-type":[{"value":"2314-6133","type":"print"},{"value":"2314-6141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015]]}}}