{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T13:00:33Z","timestamp":1788872433042,"version":"build-2803163510"},"reference-count":38,"publisher":"Wiley","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["133897\/2012-5"],"award-info":[{"award-number":["133897\/2012-5"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"National Council for Scientific and Technological Development","doi-asserted-by":"crossref","award":["133897\/2012-5"],"award-info":[{"award-number":["133897\/2012-5"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p>\n                    Despite the advances in anticancer drug discovery field, the worldwide cancer incidence is remarkable, highlighting the need for new therapies focusing on both cancer cell and its microenvironment. The tumor microenvironment offers multiple targets for cancer therapy, including inflammation. Nowadays, almost 75% of the anticancer agents used in chemotherapy are derived from natural products, and plants are an important source of new promising therapies. Continuing our research on\n                    <jats:italic>Piper umbellatum<\/jats:italic>\n                    species, here we describe the anticancer (\n                    <jats:italic>in vitro<\/jats:italic>\n                    antiproliferative activity and\n                    <jats:italic>in vivo<\/jats:italic>\n                    Ehrlich solid tumor model) and anti-inflammatory (carrageenan-induced paw edema and peritonitis models) activities of a standardized dichloromethane extract (SDE) from\n                    <jats:italic>P. umbellatum<\/jats:italic>\n                    leaves, containing 23.9% of 4-nerolidylcatechol. SDE showed\n                    <jats:italic>in vitro<\/jats:italic>\n                    and\n                    <jats:italic>in vivo<\/jats:italic>\n                    antiproliferative activity, reducing Ehrlich solid tumor growth by 38.7 and 52.2% when doses of 200 and 400\u2009mg\/kg, respectively, were administered daily by oral route. Daily treatments did not produce signals of toxicity. SDE also reduced paw edema and leukocyte migration on carrageenan-induced inflammation models, suggesting that the anticancer activity of SDE from\n                    <jats:italic>Piper umbellatum<\/jats:italic>\n                    leaves could involve antiproliferative and anti-inflammatory effects. These findings highlight\n                    <jats:italic>P. umbellatum<\/jats:italic>\n                    as a source of compounds against cancer and inflammation.\n                  <\/jats:p>","DOI":"10.1155\/2015\/948737","type":"journal-article","created":{"date-parts":[[2015,2,3]],"date-time":"2015-02-03T16:01:08Z","timestamp":1422979268000},"page":"1-8","source":"Crossref","is-referenced-by-count":28,"title":["Anticancer and Anti-Inflammatory Activities of a Standardized Dichloromethane Extract from\n                    <i>Piper umbellatum<\/i>\n                    L. Leaves"],"prefix":"10.1155","volume":"2015","author":[{"given":"Leilane Hespporte","family":"Iwamoto","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Anaesthesiology and Therapeutics, Faculty of Dentistry, University of Campinas, Avenida Limeira 901, 13414-903 Piracicaba, SP, Brazil"},{"name":"Chemical, Biological and Agricultural Pluridisciplinary Research Center (CPQBA), University of Campinas, Rua Alexandre Cazelatto 999, Vila Betel, 13148-218 Paul\u00ednia, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D\u00e9bora Barbosa","family":"Vendramini-Costa","sequence":"additional","affiliation":[{"name":"Chemical, Biological and Agricultural Pluridisciplinary Research Center (CPQBA), University of Campinas, Rua Alexandre Cazelatto 999, Vila Betel, 13148-218 Paul\u00ednia, SP, Brazil"},{"name":"Department of Organic Chemistry, Institute of Chemistry, University of Campinas, Rua Josu\u00e9 de Castro s\/n, Cidade Universit\u00e1ria Zeferino Vaz, Bar\u00e3o Geraldo, 13081-970 Campinas, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula Ara\u00fajo","family":"Monteiro","sequence":"additional","affiliation":[{"name":"Chemical, Biological and Agricultural Pluridisciplinary Research Center (CPQBA), University of Campinas, Rua Alexandre Cazelatto 999, Vila Betel, 13148-218 Paul\u00ednia, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana L\u00facia Tasca Gois","family":"Ruiz","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Anaesthesiology and Therapeutics, Faculty of Dentistry, University of Campinas, Avenida Limeira 901, 13414-903 Piracicaba, SP, Brazil"},{"name":"Chemical, Biological and Agricultural Pluridisciplinary Research Center (CPQBA), University of Campinas, Rua Alexandre Cazelatto 999, Vila Betel, 13148-218 Paul\u00ednia, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilza Maria de Oliveira","family":"Sousa","sequence":"additional","affiliation":[{"name":"Chemical, Biological and Agricultural Pluridisciplinary Research Center (CPQBA), University of Campinas, Rua Alexandre Cazelatto 999, Vila Betel, 13148-218 Paul\u00ednia, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary Ann","family":"Foglio","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Anaesthesiology and Therapeutics, Faculty of Dentistry, University of Campinas, Avenida Limeira 901, 13414-903 Piracicaba, SP, Brazil"},{"name":"Chemical, Biological and Agricultural Pluridisciplinary Research Center (CPQBA), University of Campinas, Rua Alexandre Cazelatto 999, Vila Betel, 13148-218 Paul\u00ednia, SP, Brazil"},{"name":"Faculty of Pharmaceutical Sciences, University of Campinas, Cidade Universit\u00e1ria Zeferino Vaz, 13081-970 Campinas, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o Ernesto","family":"de Carvalho","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Anaesthesiology and Therapeutics, Faculty of Dentistry, University of Campinas, Avenida Limeira 901, 13414-903 Piracicaba, SP, Brazil"},{"name":"Chemical, Biological and Agricultural Pluridisciplinary Research Center (CPQBA), University of Campinas, Rua Alexandre Cazelatto 999, Vila Betel, 13148-218 Paul\u00ednia, SP, Brazil"},{"name":"Faculty of Pharmaceutical Sciences, University of Campinas, Cidade Universit\u00e1ria Zeferino Vaz, 13081-970 Campinas, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodney Alexandre Ferreira","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Anaesthesiology and Therapeutics, Faculty of Dentistry, University of Campinas, Avenida Limeira 901, 13414-903 Piracicaba, SP, Brazil"},{"name":"Chemical, Biological and Agricultural Pluridisciplinary Research Center (CPQBA), University of Campinas, Rua 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