{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T02:31:50Z","timestamp":1788834710636,"version":"build-2803163510"},"reference-count":43,"publisher":"Wiley","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["MOP-61818"],"award-info":[{"award-number":["MOP-61818"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["MOP-106479"],"award-info":[{"award-number":["MOP-106479"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["MOP-61818"],"award-info":[{"award-number":["MOP-61818"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["MOP-106479"],"award-info":[{"award-number":["MOP-106479"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000222","name":"Heart and Stroke Foundation of Canada","doi-asserted-by":"publisher","award":["MOP-61818"],"award-info":[{"award-number":["MOP-61818"]}],"id":[{"id":"10.13039\/501100000222","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000222","name":"Heart and Stroke Foundation of Canada","doi-asserted-by":"publisher","award":["MOP-106479"],"award-info":[{"award-number":["MOP-106479"]}],"id":[{"id":"10.13039\/501100000222","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Quebec Heart Institute Corporation","award":["MOP-61818"],"award-info":[{"award-number":["MOP-61818"]}]},{"name":"Quebec Heart Institute Corporation","award":["MOP-106479"],"award-info":[{"award-number":["MOP-106479"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p>Patients with left ventricle (LV) volume overload (VO) remain in a compensated state for many years although severe dilation is present. The myocardial capacity to fulfill its energetic demand may delay decompensation. We performed a gene expression profile, a model of chronic VO in rat LV with severe aortic valve regurgitation (AR) for 9 months, and focused on the study of genes associated with myocardial energetics.<jats:italic>Methods<\/jats:italic>. LV gene expression profile was performed in rats after 9 months of AR and compared to sham-operated controls. LV glucose and fatty acid (FA) uptake was also evaluated<jats:italic>in vivo<\/jats:italic>by positron emission tomography in 8-week AR rats treated or not with fenofibrate, an activator of FA oxidation (FAO).<jats:italic>Results<\/jats:italic>. Many LV genes associated with mitochondrial function and metabolism were downregulated in AR rats. FA<jats:italic>\u03b2<\/jats:italic>-oxidation capacity was significantly impaired as early as two weeks after AR. Treatment with fenofibrate, a PPAR<jats:italic>\u03b1<\/jats:italic>agonist, normalized both FA and glucose uptake while reducing LV dilation caused by AR.<jats:italic>Conclusion<\/jats:italic>. Myocardial energy substrate preference is affected early in the evolution of LV-VO cardiomyopathy. Maintaining a relatively normal FA utilization in the myocardium could translate into less glucose uptake and possibly lesser LV remodeling.<\/jats:p>","DOI":"10.1155\/2015\/949624","type":"journal-article","created":{"date-parts":[[2015,10,25]],"date-time":"2015-10-25T17:02:33Z","timestamp":1445792553000},"page":"1-15","source":"Crossref","is-referenced-by-count":9,"title":["Transcriptional Changes Associated with Long-Term Left Ventricle Volume Overload in Rats: Impact on Enzymes Related to Myocardial Energy Metabolism"],"prefix":"10.1155","volume":"2015","author":[{"given":"Elise","family":"Roussel","sequence":"first","affiliation":[{"name":"Groupe de Recherche sur les Valvulopathies, Centre de Recherche, Institut Universitaire de Cardiologie et de Pneumologie de Qu\u00e9bec, Universit\u00e9 Laval, Quebec City, QC, Canada G1V 4G5"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Claude","family":"Drolet","sequence":"additional","affiliation":[{"name":"Groupe de Recherche sur les Valvulopathies, Centre de Recherche, Institut Universitaire de Cardiologie et de Pneumologie de Qu\u00e9bec, Universit\u00e9 Laval, Quebec City, QC, Canada G1V 4G5"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth","family":"Walsh-Wilkinson","sequence":"additional","affiliation":[{"name":"Groupe de Recherche sur les Valvulopathies, Centre de Recherche, Institut Universitaire de Cardiologie et de Pneumologie de Qu\u00e9bec, Universit\u00e9 Laval, Quebec City, QC, Canada G1V 4G5"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wahiba","family":"Dhahri","sequence":"additional","affiliation":[{"name":"Groupe de Recherche sur les Valvulopathies, Centre de Recherche, Institut Universitaire de Cardiologie et de Pneumologie de Qu\u00e9bec, Universit\u00e9 Laval, Quebec City, QC, Canada G1V 4G5"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominic","family":"Lachance","sequence":"additional","affiliation":[{"name":"Groupe de Recherche sur les Valvulopathies, Centre de Recherche, Institut Universitaire de Cardiologie et de Pneumologie de Qu\u00e9bec, Universit\u00e9 Laval, Quebec City, QC, Canada G1V 4G5"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzanne","family":"Gascon","sequence":"additional","affiliation":[{"name":"Sherbrooke Molecular Imaging Center, Research Center of Centre Hospitalier Universitaire de Sherbrooke (CRCHUS), Universit\u00e9 de Sherbrooke, Sherbrooke, QC, Canada J1H 5N4"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Otman","family":"Sarrhini","sequence":"additional","affiliation":[{"name":"Sherbrooke Molecular Imaging Center, Research Center of Centre Hospitalier Universitaire de Sherbrooke (CRCHUS), Universit\u00e9 de Sherbrooke, Sherbrooke, QC, Canada J1H 5N4"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques A.","family":"Rousseau","sequence":"additional","affiliation":[{"name":"Sherbrooke Molecular Imaging Center, Research Center of Centre Hospitalier Universitaire de Sherbrooke (CRCHUS), Universit\u00e9 de Sherbrooke, Sherbrooke, QC, Canada J1H 5N4"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger","family":"Lecomte","sequence":"additional","affiliation":[{"name":"Sherbrooke Molecular Imaging Center, Research Center of Centre Hospitalier Universitaire de Sherbrooke (CRCHUS), Universit\u00e9 de Sherbrooke, Sherbrooke, QC, Canada J1H 5N4"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques","family":"Couet","sequence":"additional","affiliation":[{"name":"Groupe de Recherche sur les Valvulopathies, Centre de Recherche, Institut Universitaire de Cardiologie et de Pneumologie de Qu\u00e9bec, Universit\u00e9 Laval, Quebec City, QC, Canada G1V 4G5"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Arsenault","sequence":"additional","affiliation":[{"name":"Groupe de Recherche sur les Valvulopathies, Centre de Recherche, Institut Universitaire de Cardiologie et de Pneumologie de Qu\u00e9bec, Universit\u00e9 Laval, Quebec City, QC, Canada G1V 4G5"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.08.1025"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.02.536"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/s1473-3099(05)70267-x"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(05)66874-2"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1177\/1753944714527490"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.108.826230"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1291\/hypres.29.1029"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.01046.2008"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1161\/circheartfailure.108.845487"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.01286.2007"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1249\/mss.0b013e318195b938"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00199.2010"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1161\/circheartfailure.112.000045"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2261-14-190"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2012.10.022"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2261-14-123"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1054\/jcaf.2003.17"},{"issue":"1","key":"18","first-page":"128","volume":"11","year":"2002","journal-title":"Journal of Heart Valve Disease"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btg345"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2003-4-10-r70"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.110.958512"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00560.2009"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1007\/s11307-008-0171-2"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1016\/j.nucmedbio.2011.07.010"},{"issue":"10","key":"25","first-page":"1655","volume":"44","year":"2003","journal-title":"Journal of Nuclear Medicine"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.4172\/2155-9880.1000217"},{"issue":"11","key":"27","first-page":"1924","volume":"45","year":"2004","journal-title":"Journal of Nuclear Medicine"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1006\/phrs.2001.0871"},{"issue":"3","key":"29","first-page":"300","volume":"17","year":"2008","journal-title":"Journal of Heart Valve Disease"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1097\/maj.0000000000000255"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2006.06.083"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.01246.2003"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1097\/FJC.0000000000000036"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2013.03.006"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.1152\/physiolgenomics.90296.2008"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvn001"},{"key":"37","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.107.086926"},{"key":"38","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2010.11.002"},{"key":"39","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00002.2009"},{"key":"40","doi-asserted-by":"publisher","DOI":"10.1161\/hypertensionaha.107.092403"},{"key":"41","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.01104.2010"},{"key":"42","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2003.11.004"},{"key":"43","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/541394"}],"container-title":["BioMed Research International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2015\/949624.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2015\/949624.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2015\/949624.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2016,8,19]],"date-time":"2016-08-19T01:41:05Z","timestamp":1471570865000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/bmri\/2015\/949624\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":43,"alternative-id":["949624","949624"],"URL":"https:\/\/doi.org\/10.1155\/2015\/949624","relation":{},"ISSN":["2314-6133","2314-6141"],"issn-type":[{"value":"2314-6133","type":"print"},{"value":"2314-6141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015]]}}}