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Monocyte is a significant source of inflammatory cytokines in vascular remodeling. Telmisartan could reduce inflammation. In our study, we first found that, after CAS, the serum IL\u20101<jats:italic>\u03b2<\/jats:italic>, IL\u20106, TGF\u2010<jats:italic>\u03b2<\/jats:italic>, and MMP\u20109 levels were significantly increased, but only MMP\u20109 level was elevated no less than 3 months. Second, we established a new <jats:italic>in vitro<\/jats:italic> model, where THP\u20101 monocytes were treated with the supernatants of human umbilical vein endothelial cells (HUVECs) that were scratched by pipette tips, which mimics monocytes activated by mechanical injury of stenting. The treatment enhanced THP\u20101 cell adhesion, migration and invasion ability, and the phosphorylation of ERK1\/2 and Elk\u20101 and MMP\u20109 expression were significantly increased. THP\u20101 cells pretreated with PD98095 (ERK1\/2 inhibitor) attenuated the phosphorylation of ERK1\/2 and Elk\u20101 and upregulation of MMP\u20109, while pretreatment with telmisartan merely decreased the phosphorylation of Elk\u20101 and MMP\u20109 expression. These results suggested that IL\u20101<jats:italic>\u03b2<\/jats:italic>, IL\u20106, TGF\u2010<jats:italic>\u03b2<\/jats:italic>, and MMP\u20109 participate in the pathophysiological process after CAS. Our new <jats:italic>in vitro<\/jats:italic> model mimics monocytes activated by stenting. MMP\u20109 expression could be regulated through ERK1\/2\/Elk\u20101 pathway, and the protective effects of telmisartan after stenting are partly attributed to its MMP\u20109 inhibition effects via suppression of Elk\u20101.<\/jats:p>","DOI":"10.1155\/2015\/956082","type":"journal-article","created":{"date-parts":[[2015,5,31]],"date-time":"2015-05-31T21:03:14Z","timestamp":1433106194000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Serum Levels of IL\u20101<i>\u03b2<\/i>, IL\u20106, TGF\u2010<i>\u03b2<\/i>, and MMP\u20109 in Patients Undergoing Carotid Artery Stenting and Regulation of MMP\u20109 in a New <i>In Vitro<\/i> Model of THP\u20101 Cells Activated by Stenting"],"prefix":"10.1155","volume":"2015","author":[{"given":"Rongrong","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cindy Si","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianzhu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinzhou","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Tao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyue","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,5,31]]},"reference":[{"key":"e_1_2_8_1_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000110311.09970.83"},{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0022683"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2011.05.025"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjca.2012.05.012"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000037100.44766.5B"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2009.05.036"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-013-9647-6"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2009.10.023"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000226544.93089.7f"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2005.06.002"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.atv.0000251021.28725.e8"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/928315"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.atv.0000256467.25384.c6"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.103.25.3117"},{"key":"e_1_2_8_15_2","doi-asserted-by":"publisher","DOI":"10.1191\/1358863x03vm462oa"},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-10-0544"},{"key":"e_1_2_8_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/00041433-199912000-00004"},{"key":"e_1_2_8_18_2","first-page":"199","article-title":"Interactions of monocytic cells with human endothelial cells stimulate monocytic metalloproteinase production","volume":"152","author":"Amorino G. 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