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She has since remained seizure-free on felbamate monotherapy. Although felbamate has multiple mechanisms of action, it is thought to have its most potent antiepileptic effects through inhibition of the<jats:italic>N<\/jats:italic>-methyl-D-aspartate receptor (NMDAR). Previous studies have shown that the NMDAR is altered in varying epilepsy syndromes and notably in the cortical tubers found in TSC. The aim of this paper is to examine how felbamate monotherapy was able to achieve such robust antiepileptic effects in a unique patient and possibly offer a novel therapeutic approach to patients suffering from TSC- and NF-related epilepsy.<\/jats:p>","DOI":"10.1155\/2015\/960746","type":"journal-article","created":{"date-parts":[[2015,10,22]],"date-time":"2015-10-22T21:04:27Z","timestamp":1445547867000},"page":"1-8","source":"Crossref","is-referenced-by-count":2,"title":["A Potential Role for Felbamate in TSC- and NF1-Related Epilepsy: A Case Report and Review of the Literature"],"prefix":"10.1155","volume":"2015","author":[{"given":"Natanya M.","family":"Mishal","sequence":"first","affiliation":[{"name":"Division of Neurology, Department of Pediatrics, Rady Children\u2019s Hospital San Diego and University of California San Diego, San Diego, CA 92123, 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