{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T19:02:57Z","timestamp":1740164577292,"version":"3.37.3"},"reference-count":10,"publisher":"Wiley","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Oncological Medicine"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p><jats:italic>Purpose<\/jats:italic>. To describe tumor shrinkage of nonirradiated lung metastases in a patient with non-small cell lung cancer.<jats:italic>Case Report<\/jats:italic>. The patient had a concurrent autoimmune condition, bullous pemphigoid, which was clinically exacerbated during radiotherapy of mediastinal and axillary lymph node metastases. He also developed a series of infections during and after irradiation, and we hypothesize that the immunological events during this phase might have influenced the size of the nonirradiated metastases.<jats:italic>Conclusion<\/jats:italic>. Ionizing radiation generates inflammatory signals and, in principle, could provide both tumor-specific antigens from dying cells and maturation stimuli that are necessary for dendritic cells\u2019 activation of tumor-specific T cells. Even if the detailed mechanisms causing nontargeted immune modulatory effects in individual patients are poorly understood, clinical development of radioimmunotherapy is underway.<\/jats:p>","DOI":"10.1155\/2015\/964687","type":"journal-article","created":{"date-parts":[[2015,8,9]],"date-time":"2015-08-09T17:03:58Z","timestamp":1439139838000},"page":"1-4","source":"Crossref","is-referenced-by-count":2,"title":["Nontargeted Effect after Radiotherapy in a Patient with Non-Small Cell Lung Cancer and Bullous Pemphigoid"],"prefix":"10.1155","volume":"2015","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1592-2908","authenticated-orcid":true,"given":"Carsten","family":"Nieder","sequence":"first","affiliation":[{"name":"Department of Oncology and Palliative Medicine, Nordland Hospital, 8092 Bod\u00f8, Norway"},{"name":"Department of Clinical Medicine, Faculty of Health Sciences, University of Troms\u00f8, 9038 Troms\u00f8, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khalid","family":"Al-Shibli","sequence":"additional","affiliation":[{"name":"Department of Pathology, Nordland Hospital, 8092 Bod\u00f8, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Terje","family":"Toll\u00e5li","sequence":"additional","affiliation":[{"name":"Department of Pulmonology, Nordland Hospital, 8092 Bod\u00f8, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2003.09.012"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.ccr-07-4485"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2013.09.015"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-013-1399-5"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1186\/2193-1801-3-217"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1007\/s00066-013-0507-y"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1007\/s00066-013-0360-z"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1158\/2326-6066.cir-13-0115"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.2217\/imt.14.38"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1667\/rr13707.1"}],"container-title":["Case Reports in Oncological Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/crionm\/2015\/964687.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crionm\/2015\/964687.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crionm\/2015\/964687.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2016,8,19]],"date-time":"2016-08-19T00:08:06Z","timestamp":1471565286000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/crionm\/2015\/964687\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":10,"alternative-id":["964687","964687"],"URL":"https:\/\/doi.org\/10.1155\/2015\/964687","relation":{},"ISSN":["2090-6706","2090-6714"],"issn-type":[{"type":"print","value":"2090-6706"},{"type":"electronic","value":"2090-6714"}],"subject":[],"published":{"date-parts":[[2015]]}}}