{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T01:29:06Z","timestamp":1788571746162,"version":"build-2803163510"},"reference-count":51,"publisher":"Wiley","license":[{"start":{"date-parts":[[2015,11,18]],"date-time":"2015-11-18T00:00:00Z","timestamp":1447804800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/100007188","name":"Uniformed Services University","doi-asserted-by":"crossref","award":["R091DK"],"award-info":[{"award-number":["R091DK"]}],"id":[{"id":"10.13039\/100007188","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biomarkers"],"published-print":{"date-parts":[[2015,11,18]]},"abstract":"<jats:p>Variations of baseline plasma concentrations of creatine kinase (CK), heat shock protein 70 (HSP70), and interleukin 6 (IL-6) have been reported. We report categorical associations which may influence these protein levels.<jats:italic> Methods<\/jats:italic>. Blood was harvested for DNA and plasma protein analysis from 567 adults. Mean protein levels of CK, HSP70, and IL-6 were compared by sex, ethnicity, genetic variants\u2014CKMM Nco1 (rs1803285), HSPA1B +A1538G (rs1061581), and<jats:italic> IL6<\/jats:italic> G-174C (rs1800795)\u2014self-reported history of exercise, oral contraceptive use, and dietary supplement use.<jats:italic> Results<\/jats:italic>. SNP major allele frequencies for CKMM, HSPA1B, and<jats:italic> IL6<\/jats:italic> were 70% A, 57% A, and 60%. Mean CK statistically differed by sex, ethnicity, oral contraceptives, and caffeine. Plasma HSP70 differed by caffeine and protein. Mean IL-6 concentration differed by sex, ethnicity, and genotype. Plasma IL-6 was significantly lower (29%) in males (1.92 \u00b1 0.08\u2009pg\/mL) and higher (29%) among African Americans (2.85 \u00b1 0.50\u2009pg\/mL) relative to the others.<jats:italic> IL6<\/jats:italic> G-174C GG genotype (2.23 \u00b1 0.14\u2009pg\/mL) was 19% greater than CG or CC genotypes.<jats:italic> Conclusion<\/jats:italic>. Differences in baseline CK and IL-6 plasma protein concentrations are associated with genetics, sex, ethnicity, and the use of oral contraceptives, caffeine, and protein supplements in this young and athletic population.<\/jats:p>","DOI":"10.1155\/2015\/967120","type":"journal-article","created":{"date-parts":[[2015,11,18]],"date-time":"2015-11-18T21:05:00Z","timestamp":1447880700000},"page":"1-8","source":"Crossref","is-referenced-by-count":4,"title":["Association of Plasma Heat Shock Protein 70, Interleukin 6, and Creatine Kinase Concentrations in a Healthy, Young Adult Population"],"prefix":"10.1155","volume":"2015","author":[{"given":"Carmen","family":"Contreras-Sesvold","sequence":"first","affiliation":[{"name":"Human Performance Laboratory, Department of Military and Emergency Medicine, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bradley 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