{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T07:18:44Z","timestamp":1789543124756,"version":"build-2803163510"},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,1,13]],"date-time":"2015-01-13T00:00:00Z","timestamp":1421107200000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Scientific World Journal"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:p><jats:italic>Objectives<\/jats:italic>. This study was conducted to review systematically adjunctive treatments for weight reduction in patients with schizophrenia and compare efficacies of clinical trials through meta\u2010analysis, so as to provide effective clinical guideline regarding weight control for patients taking atypical antipsychotics. <jats:italic>Methods<\/jats:italic>. Candidate clinical trials were identified through searching the Cochrane Central Register of Controlled Trials, PubMed, and PsycINFO. Fourteen randomized clinical trials were included for systematic review and meta\u2010analysis from 132 potential trials. The Comprehensive Meta\u2010Analysis version 2 was used for meta\u2010analysis. <jats:italic>Results<\/jats:italic>. Difference in means and significances from meta\u2010analyses regarding weight control by adjunctive treatments showed that topiramate, aripiprazole, or sibutramine was more effective than metformin or reboxetine. Psychiatric evaluations did not show statistically significant changes between treatment groups and placebo groups except topiramate adjunctive treatments. Adverse effects regarding adjunctive therapies were tolerable and showed statistically no significances compared to control groups. <jats:italic>Conclusion<\/jats:italic>. Though having several reports related to exacerbation of psychiatric symptoms, topiramate and aripiprazole are more efficacious than other medications in regard to weight reduction and less burden of critical adverse effects as well as being beneficial for clinical improvement.<\/jats:p>","DOI":"10.1155\/2015\/970730","type":"journal-article","created":{"date-parts":[[2015,1,13]],"date-time":"2015-01-13T21:55:13Z","timestamp":1421186113000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Efficacy of Adjunctive Treatments Added to Olanzapine or Clozapine for Weight Control in Patients with Schizophrenia: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1155","volume":"2015","author":[{"given":"Yun-Jung","family":"Choi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,1,13]]},"reference":[{"key":"e_1_2_7_1_2","first-page":"e234","article-title":"Topiramate\u2014induced weight loss in schizophrenia: a retrospective case series study","volume":"14","author":"L\u00e9vy E.","year":"2007","journal-title":"Canadian Journal of Clinical Pharmacology"},{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1300027"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/01213011-200504000-00002"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2010.21"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1177\/070674370104600610"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1177\/0269881110372548"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.162.5.954"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1017\/s1461145710000490"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2010.02.001"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1177\/0269881108089816"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2008.01.011"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2007.07010079"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2007.03.029"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.2006.00855.x"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-007-0731-1"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1177\/070674370605100310"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2003.10.004"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0924-977x(02)00127-x"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.160.2.297"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.159.6.1058"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2004-832593"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.2005.02407.x"},{"key":"e_1_2_7_23_2","first-page":"213","article-title":"Effect of the selective norepinephrine reuptake inhibitor reboxetine on cognitive dysfunction in schizophrenia patients: an add-on, double-blind placebo-controlled study","volume":"46","author":"Poyurovsky M.","year":"2009","journal-title":"The Israel Journal of Psychiatry and Related Sciences"},{"key":"e_1_2_7_24_2","unstructured":"RadulovicL. 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