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To know the principles of treatment it is essential to understand the underlying pathophysiological mechanisms that cause the need of diuresis in the human body. Various classes of diuretics exist, each having a unique mode of action. A systemic approach for management is recommended based on the current guidelines, starting from thiazides and proceeding to loop diuretics. The first condition for discussion in the paper is cardiac failure. Treatment of ascites in liver cirrhosis with spironolactone as the primary agent is highlighted with further therapeutic options. Lastly, management choices for nephrotic syndrome are discussed and recommended beginning from basic sodium restriction to combined diuretic therapies. Major side effects are discussed.<\/jats:p>","DOI":"10.1155\/2015\/975934","type":"journal-article","created":{"date-parts":[[2015,7,29]],"date-time":"2015-07-29T21:04:32Z","timestamp":1438203872000},"page":"1-9","source":"Crossref","is-referenced-by-count":45,"title":["Clinical Use of Diuretics in Heart Failure, Cirrhosis, and Nephrotic Syndrome"],"prefix":"10.1155","volume":"2015","author":[{"given":"Ahmed Hassaan","family":"Qavi","sequence":"first","affiliation":[{"name":"Shifa College of Medicine, Shifa Tameer-e-Millat University, Pitras Bukhari Road, Sector H-8\/4, Islamabad 44000, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rida","family":"Kamal","sequence":"additional","affiliation":[{"name":"Shifa College of Medicine, Shifa Tameer-e-Millat University, Pitras Bukhari Road, Sector H-8\/4, Islamabad 44000, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert 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