{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:09:43Z","timestamp":1790122183962,"version":"4.0.1"},"reference-count":20,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Immunology Research"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p><jats:italic>Objective<\/jats:italic>. To evaluate the effect of anti-TNF agents plus synthetic disease modifying antirheumatic drugs (DMARDs) versus DMARDs alone for ankylosing spondylitis (AS) with reduced pulmonary function vital capacity (FVC%).<jats:italic>Methods<\/jats:italic>. In an observational study, we included AS who had FVC% &lt;80% at baseline. Twenty patients were taking DMARDs and 16 received anti-TNF + DMARDs. Outcome measures: changes in FVC%, BASDAI, BASFI, 6-minute walk test (6MWT), Borg scale after 6MWT, and St. George\u2019s Respiratory Questionnaire at 24 months.<jats:italic>Results<\/jats:italic>. Both DMARDs and anti-TNF + DMARDs groups had similar baseline values in FVC%. Significant improvement was achieved with anti-TNF + DMARDs in FVC%, at 24 months, when compared to DMARDs alone (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.04<\/mml:mn><\/mml:math>). Similarly, patients in anti-TNF + DMARDs group had greater improvement in BASDAI, BASFI, Borg scale, and 6MWT when compared to DMARDs alone. After 2 years of follow-up, 14\/16 (87.5%) in the anti-TNF + DMARDs group achieved the primary outcome: FVC% \u226580%, compared with 11\/20 (55%) in the DMARDs group (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.04<\/mml:mn><\/mml:math>).<jats:italic>Conclusions<\/jats:italic>. Patients with anti-TNF + DMARDs had a greater improvement in FVC% and cardiopulmonary scales at 24 months compared with DMARDs. This preliminary study supports the fact that anti-TNF agents may offer additional benefits compared to DMARDs in patients with AS who have reduced FVC%.<\/jats:p>","DOI":"10.1155\/2015\/980147","type":"journal-article","created":{"date-parts":[[2015,5,19]],"date-time":"2015-05-19T21:05:06Z","timestamp":1432069506000},"page":"1-8","source":"Crossref","is-referenced-by-count":2,"title":["Influence of Anti-TNF and Disease Modifying Antirheumatic Drugs Therapy on Pulmonary Forced Vital Capacity Associated to Ankylosing Spondylitis: A 2-Year Follow-Up Observational Study"],"prefix":"10.1155","volume":"2015","author":[{"given":"Alberto Daniel","family":"Rocha-Mu\u00f1oz","sequence":"first","affiliation":[{"name":"Universidad de Colima, 28046 Colima, COL, Mexico"},{"name":"Centro Universitario de Tonala, Universidad de Guadalajara, 48525 Tonala, JAL, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aniel Jessica Leticia","family":"Brambila-Tapia","sequence":"additional","affiliation":[{"name":"Centro Universitario de Ciencias de la Salud (CUCS), Universidad de Guadalajara, 44340 Guadalajara, JAL, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Guadalupe","family":"Zavala-Cerna","sequence":"additional","affiliation":[{"name":"Departamento de Inmunolog\u00eda, Facultad de Medicina, Universidad Autonoma de Guadalajara, 44670 Guadalajara, JAL, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Clemente","family":"V\u00e1squez-Jim\u00e9nez","sequence":"additional","affiliation":[{"name":"Centro Universitario de Investigacion Biomedica, Universidad de Colima, 28040 Colima, COL, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liliana Faviola","family":"De la Cerda-Trujillo","sequence":"additional","affiliation":[{"name":"Coordinaci\u00f3n de Investigacion, Division de Cirugia, Hospital Civil de Guadalajara \u201cDr. Juan I. Menchaca\u201d, 44280 Guadalajara, JAL, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00f3nica","family":"V\u00e1zquez-Del Mercado","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n en Reumatologia y del Sistema Musculoesqueletico, CUCS, Universidad de Guadalajara, 44340 Guadalajara, JAL, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norma Alejandra","family":"Rodriguez-Jimenez","sequence":"additional","affiliation":[{"name":"Centro Universitario de Ciencias de la Salud (CUCS), Universidad de Guadalajara, 44340 Guadalajara, JAL, Mexico"},{"name":"Hospital General Regional No. 110, Instituto Mexicano del Seguro Social (IMSS), 44716 Guadalajara, JAL, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria","family":"D\u00edaz-Rizo","sequence":"additional","affiliation":[{"name":"Centro Universitario de Investigacion Biomedica, Universidad de Colima, 28040 Colima, COL, Mexico"},{"name":"Unidad de Investigacion en Epidemiologia, Clinica, Hospital de Especialidades Centro Medico Nacional de Occidente (CMNO), IMSS, 44340 Guadalajara, JAL, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viviana","family":"D\u00edaz-Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Centro Universitario de Ciencias de la Salud (CUCS), Universidad de Guadalajara, 44340 Guadalajara, JAL, Mexico"},{"name":"Unidad de Investigacion en Epidemiologia, Clinica, Hospital de Especialidades Centro Medico Nacional de Occidente (CMNO), IMSS, 44340 Guadalajara, JAL, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ernesto German","family":"Cardona-Mu\u00f1oz","sequence":"additional","affiliation":[{"name":"Departamento de Fisiologia, CUCS, Universidad de Guadalajara, 44340 Guadalajara, JAL, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingrid Patricia","family":"D\u00e1valos-Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Divisi\u00f3n de Genetica, Centro de Investigacion Biomedica de Occidente, IMSS, 44340 Guadalajara, JAL, Mexico"},{"name":"Instituto de Genetica Humana, CUCS, Universidad de Guadalajara, 44340 Guadalajara, JAL, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Salazar-Paramo","sequence":"additional","affiliation":[{"name":"Departamento de Fisiologia, CUCS, Universidad de Guadalajara, 44340 Guadalajara, JAL, Mexico"},{"name":"Divisi\u00f3n de Investigacion en Salud, UMAE, CMNO, IMSS, 44340 Guadalajara, JAL, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge Ivan","family":"Gamez-Nava","sequence":"additional","affiliation":[{"name":"Centro Universitario de Ciencias de la Salud (CUCS), Universidad de Guadalajara, 44340 Guadalajara, JAL, Mexico"},{"name":"Unidad de Investigacion en Epidemiologia, Clinica, Hospital de Especialidades Centro Medico Nacional de Occidente (CMNO), IMSS, 44340 Guadalajara, JAL, Mexico"},{"name":"Departamento de Fisiologia, CUCS, Universidad de Guadalajara, 44340 Guadalajara, JAL, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnulfo Hernan","family":"Nava-Zavala","sequence":"additional","affiliation":[{"name":"Unidad de Investigacion en Epidemiologia, Clinica, Hospital de Especialidades Centro Medico Nacional de Occidente (CMNO), IMSS, 44340 Guadalajara, JAL, Mexico"},{"name":"Facultad de Medicina, Decanato de Ciencias de la Salud, Universidad Autonoma de Guadalajara, 44670 Guadalajara, JAL, Mexico"},{"name":"Servicio de Medicina Interna, Inmunologia y Reumatologia, Hospital General de Occidente, Secretaria de Salud Jalisco, 45170 Zapopan, JAL, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Gonzalez-Lopez","sequence":"additional","affiliation":[{"name":"Centro Universitario de Ciencias de la Salud (CUCS), Universidad de Guadalajara, 44340 Guadalajara, JAL, Mexico"},{"name":"Hospital General Regional No. 110, Instituto Mexicano del Seguro Social (IMSS), 44716 Guadalajara, JAL, Mexico"},{"name":"Departamento de Fisiologia, CUCS, Universidad de Guadalajara, 44340 Guadalajara, JAL, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"98","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-005-1158-x"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1186\/ar3699"},{"issue":"8","key":"3","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1053\/crad.2000.0498","volume":"55","year":"2000","journal-title":"Clinical Radiology"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1620\/tjem.212.423"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-003-0845-8"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/s0720-048x(02)00052-9"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-013-2723-2"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/965956"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2010.139261"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1002\/art.30223"},{"issue":"4","key":"11","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1002\/art.1780270401","volume":"27","year":"1984","journal-title":"Arthritis and Rheumatism"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1378\/chest.115.3.869"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.06.00036005"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.05.00034505"},{"key":"15","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1183\/09031936.05.00034805","volume":"26","year":"2005","journal-title":"The European Respiratory Journal"},{"issue":"12","key":"16","first-page":"2286","volume":"21","year":"1994","journal-title":"Journal of Rheumatology"},{"issue":"12","key":"17","first-page":"2281","volume":"21","year":"1994","journal-title":"Journal of Rheumatology"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/145.6.1321"},{"issue":"8","key":"19","first-page":"783","volume":"48","year":"2003","journal-title":"Respiratory Care"},{"issue":"5","key":"20","first-page":"377","volume":"14","year":"1982","journal-title":"Medicine & Science in Sports & Exercise"}],"container-title":["Journal of Immunology Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/jir\/2015\/980147.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/jir\/2015\/980147.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/jir\/2015\/980147.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,23]],"date-time":"2017-06-23T11:56:34Z","timestamp":1498218994000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/jir\/2015\/980147\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":20,"alternative-id":["980147","980147"],"URL":"https:\/\/doi.org\/10.1155\/2015\/980147","relation":{},"ISSN":["2314-8861","2314-7156"],"issn-type":[{"value":"2314-8861","type":"print"},{"value":"2314-7156","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015]]}}}