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However, quality control of this herbal medicine has been not satisfactory. This study reported its qualitative and quantitative analyses based on LC\/MS method. UHPLC\u2010DAD\u2010Q\u2010TOF\u2010MS fingerprinting and MS fragmentation cleavage pathway were investigated for qualitative analysis. Furthermore, a method for simultaneous quantitative determination of nine compounds, luteolin 7\u2010<jats:italic>O<\/jats:italic>\u2010<jats:italic>\u03b2<\/jats:italic>\u2010D\u2010glucopyranoside, ecliptasaponin C, luteolin, eclalbasaponin IV, apigenin, ecliptasaponin A, echinocystic acid 28\u2010<jats:italic>O<\/jats:italic>\u2010<jats:italic>\u03b2<\/jats:italic>\u2010D\u2010glucopyranoside, echinocystic acid, and 3\u2010oxo\u201016<jats:italic>\u03b1<\/jats:italic>\u2010hydroxy\u2010olean\u201012\u2010en\u201028\u2010oic acid in <jats:italic>E. prostrata<\/jats:italic>, was established. The method was validated for samples of <jats:italic>E. prostrata<\/jats:italic> from different habitats. 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