{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T07:38:03Z","timestamp":1772696283133,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. The aim of this retrospective observational study of women treated for cervical intraepithelial neoplasia grade 2 or worse (CIN2+) was to assess the long-term risk of residual\/recurrent high-grade CIN.<jats:italic>Materials and Methods<\/jats:italic>. We evaluated 760 women treated by loop electrosurgical excision procedure (684) or conization (76) between 2000 and 2009, and followed up to June 30, 2014 (median follow-up 6.7 years, range 4\u201314). Visits every 6 months for the first year after treatment and yearly for up to the following 10 years included cytology, colposcopy when indicated, and HPV testing (search and typing).<jats:italic>Results<\/jats:italic>. CIN2+ or vaginal intraepithelial neoplasia grade 2 or worse (VAIN2+) was detected in 67 cases (8.8%), 39 at first follow-up and 28 after one\/more negative visits. The risk of CIN2+ was higher in case of positive margins (odds ratio (OR) 8.04, 95% CI 4.31\u201315.0), type 3 transformation zone (OR for CIN3 27.7, 95% CI 2.07\u201336.9), CIN3+ excision (OR 6.02, 95% CI 1.73\u201320.9), and positive high-risk HPV test at first follow-up (OR for HPV16: 20.6, 95% CI 6.8\u201362.6; OR for other hrHPV types: 18.3, 95% CI 5.9\u201357.0).<jats:italic>Conclusion<\/jats:italic>. Residual\/recurrent high-grade CIN occurred in &lt;9% cases, and the risk was associated with transformation zone type, lesion grade, margins status, and hrHPV test result at 6\u201312 months of follow-up.<\/jats:p>","DOI":"10.1155\/2015\/984528","type":"journal-article","created":{"date-parts":[[2015,6,10]],"date-time":"2015-06-10T17:46:13Z","timestamp":1433958373000},"page":"1-8","source":"Crossref","is-referenced-by-count":19,"title":["Long-Term Clinical Outcome after Treatment for High-Grade Cervical Lesions: A Retrospective Monoinstitutional Cohort Study"],"prefix":"10.1155","volume":"2015","author":[{"given":"Annarosa","family":"Del Mistro","sequence":"first","affiliation":[{"name":"Immunology and Molecular Oncology Unit, Veneto Institute of Oncology-(IOV-) IRCCS, Via Gattamelata 64, 35128 Padua, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario","family":"Matteucci","sequence":"additional","affiliation":[{"name":"Department of Woman and Child Health, 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