{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T10:58:46Z","timestamp":1774522726158,"version":"3.50.1"},"reference-count":56,"publisher":"Wiley","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pulmonary Medicine"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p><jats:italic>Introduction<\/jats:italic>. Endobronchial ultrasound (EBUS) is a procedure that provides access to the mediastinal staging; however, EBUS cannot be used to stage all of the nodes in the mediastinum. In these cases, endoscopic ultrasound (EUS) is used for complete staging.<jats:italic>Objective<\/jats:italic>. To provide a synthesis of the evidence on the diagnostic performance of EBUS + EUS in patients undergoing mediastinal staging.<jats:italic>Methods<\/jats:italic>. Systematic review and meta-analysis to evaluate the diagnostic yield of EBUS + EUS compared with surgical staging. Two researchers performed the literature search, quality assessments, data extractions, and analyses. We produced a meta-analysis including sensitivity, specificity, and likelihood ratio analysis.<jats:italic>Results<\/jats:italic>. Twelve primary studies (1515 patients) were included; two were randomized controlled trials (RCTs) and ten were prospective trials. The pooled sensitivity for combined EBUS + EUS was 87% (CI 84\u201389%) and the specificity was 99% (CI 98\u2013100%). For EBUS + EUS performed with a single bronchoscope group, the sensitivity improved to 88% (CI 83.1\u201391.4%) and specificity improved to 100% (CI 99-100%).<jats:italic>Conclusion<\/jats:italic>. EBUS + EUS is a highly accurate and safe procedure. The combined procedure should be considered in selected patients with lymphadenopathy noted at stations that are not traditionally accessible with conventional EBUS.<\/jats:p>","DOI":"10.1155\/2016\/1024709","type":"journal-article","created":{"date-parts":[[2016,10,13]],"date-time":"2016-10-13T17:07:10Z","timestamp":1476378430000},"page":"1-11","source":"Crossref","is-referenced-by-count":23,"title":["Minimally Invasive Methods for Staging in Lung Cancer: Systematic Review and Meta-Analysis"],"prefix":"10.1155","volume":"2016","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0069-3420","authenticated-orcid":true,"given":"Gonzalo","family":"Labarca","sequence":"first","affiliation":[{"name":"Facultad de Medicina, Universidad San Sebasti\u00e1n, Lientur 1457, Concepci\u00f3n 4080871, Chile"},{"name":"Division of Internal Medicine, Complejo Asistencial Victor Rios Ruiz, Los Angeles, 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