{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T14:42:09Z","timestamp":1784126529926,"version":"3.55.0"},"reference-count":47,"publisher":"Wiley","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31571832"],"award-info":[{"award-number":["31571832"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81172837"],"award-info":[{"award-number":["81172837"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["201510069043"],"award-info":[{"award-number":["201510069043"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["TD-12-5049"],"award-info":[{"award-number":["TD-12-5049"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["13JCQNJC12200"],"award-info":[{"award-number":["13JCQNJC12200"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31571832"],"award-info":[{"award-number":["31571832"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81172837"],"award-info":[{"award-number":["81172837"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["201510069043"],"award-info":[{"award-number":["201510069043"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["TD-12-5049"],"award-info":[{"award-number":["TD-12-5049"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["13JCQNJC12200"],"award-info":[{"award-number":["13JCQNJC12200"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Student Innovation Programme","award":["31571832"],"award-info":[{"award-number":["31571832"]}]},{"name":"National Student Innovation Programme","award":["81172837"],"award-info":[{"award-number":["81172837"]}]},{"name":"National Student Innovation Programme","award":["201510069043"],"award-info":[{"award-number":["201510069043"]}]},{"name":"National Student Innovation Programme","award":["TD-12-5049"],"award-info":[{"award-number":["TD-12-5049"]}]},{"name":"National Student Innovation Programme","award":["13JCQNJC12200"],"award-info":[{"award-number":["13JCQNJC12200"]}]},{"name":"Tianjin Innovative Research Team Grant","award":["31571832"],"award-info":[{"award-number":["31571832"]}]},{"name":"Tianjin Innovative Research Team Grant","award":["81172837"],"award-info":[{"award-number":["81172837"]}]},{"name":"Tianjin Innovative Research Team Grant","award":["201510069043"],"award-info":[{"award-number":["201510069043"]}]},{"name":"Tianjin Innovative Research Team Grant","award":["TD-12-5049"],"award-info":[{"award-number":["TD-12-5049"]}]},{"name":"Tianjin Innovative Research Team Grant","award":["13JCQNJC12200"],"award-info":[{"award-number":["13JCQNJC12200"]}]},{"DOI":"10.13039\/501100010041","name":"Tianjin Municipal Science and Technology Commission","doi-asserted-by":"crossref","award":["31571832"],"award-info":[{"award-number":["31571832"]}],"id":[{"id":"10.13039\/501100010041","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100010041","name":"Tianjin Municipal Science and Technology Commission","doi-asserted-by":"crossref","award":["81172837"],"award-info":[{"award-number":["81172837"]}],"id":[{"id":"10.13039\/501100010041","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100010041","name":"Tianjin Municipal Science and Technology Commission","doi-asserted-by":"crossref","award":["201510069043"],"award-info":[{"award-number":["201510069043"]}],"id":[{"id":"10.13039\/501100010041","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100010041","name":"Tianjin Municipal Science and Technology Commission","doi-asserted-by":"crossref","award":["TD-12-5049"],"award-info":[{"award-number":["TD-12-5049"]}],"id":[{"id":"10.13039\/501100010041","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100010041","name":"Tianjin Municipal Science and Technology Commission","doi-asserted-by":"crossref","award":["13JCQNJC12200"],"award-info":[{"award-number":["13JCQNJC12200"]}],"id":[{"id":"10.13039\/501100010041","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p>Hyperoside, an active compound found in plants of the genera<jats:italic>Hypericum<\/jats:italic>and<jats:italic>Crataegus<\/jats:italic>, is reported to exhibit antioxidant, anticancer, and anti-inflammatory activities. Induction of hepatic stellate cell (HSC) apoptosis is recognized as a promising strategy for attenuation of hepatic fibrosis. In this study, we investigated whether hyperoside treatment can exert antifibrotic effects in human LX-2 hepatic stellate cells. We found that hyperoside induced apoptosis in LX-2 cells and decreased levels of<jats:italic>\u03b1<\/jats:italic>-smooth muscle actin (<jats:italic>\u03b1<\/jats:italic>-SMA), type I collagen, and intracellular reactive oxygen species (ROS). Remarkably, hyperoside also inhibited the DNA-binding activity of the transcription factor NF-<jats:italic>\u03ba<\/jats:italic>B and altered expression levels of NF-<jats:italic>\u03ba<\/jats:italic>B-regulated genes related to apoptosis, including proapoptotic genes<jats:italic>Bcl-Xs<\/jats:italic>,<jats:italic>DR4<\/jats:italic>,<jats:italic>Fas<\/jats:italic>, and<jats:italic>FasL<\/jats:italic>and anti-apoptotic genes<jats:italic>A20<\/jats:italic>,<jats:italic>c-IAP1<\/jats:italic>,<jats:italic>Bcl-<\/jats:italic><mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mrow><mml:msub><mml:mrow><mml:mi>X<\/mml:mi><\/mml:mrow><mml:mrow><mml:mi>L<\/mml:mi><\/mml:mrow><\/mml:msub><\/mml:mrow><\/mml:math>, and<jats:italic>RIP1<\/jats:italic>. Our results suggest that hyperoside may have potential as a therapeutic agent for the treatment of liver fibrosis.<\/jats:p>","DOI":"10.1155\/2016\/1068528","type":"journal-article","created":{"date-parts":[[2016,3,27]],"date-time":"2016-03-27T21:00:41Z","timestamp":1459112441000},"page":"1-10","source":"Crossref","is-referenced-by-count":17,"title":["Dietary Flavonoid Hyperoside Induces Apoptosis of Activated Human LX-2 Hepatic Stellate Cell by Suppressing Canonical NF-<i>\u03ba<\/i>B Signaling"],"prefix":"10.1155","volume":"2016","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7135-3418","authenticated-orcid":true,"given":"Liwen","family":"Wang","sequence":"first","affiliation":[{"name":"Tianjin Key Laboratory of Food and Biotechnology, School of Biotechnology and Food Science, Tianjin University of Commerce, Tianjin 300134, China"},{"name":"Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300192, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7579-148X","authenticated-orcid":true,"given":"Zhiwei","family":"Yue","sequence":"additional","affiliation":[{"name":"Department of Hematology and Tangshan Key Laboratory, Translational Medical Center, North China University of Science and Technology, Tangshan, Hebei 063000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4788-8073","authenticated-orcid":true,"given":"Mengzheng","family":"Guo","sequence":"additional","affiliation":[{"name":"Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300192, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9423-1621","authenticated-orcid":true,"given":"Lianying","family":"Fang","sequence":"additional","affiliation":[{"name":"Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300192, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Bai","sequence":"additional","affiliation":[{"name":"Tianjin Key Laboratory of Food and Biotechnology, School of Biotechnology and Food Science, Tianjin University of Commerce, Tianjin 300134, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0871-7992","authenticated-orcid":true,"given":"Xinyu","family":"Li","sequence":"additional","affiliation":[{"name":"Tianjin Key Laboratory of Food and Biotechnology, School of Biotechnology and Food Science, Tianjin University of Commerce, Tianjin 300134, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongqing","family":"Tao","sequence":"additional","affiliation":[{"name":"Tianjin Key Laboratory of Food and Biotechnology, School of Biotechnology and Food Science, Tianjin University of Commerce, Tianjin 300134, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suying","family":"Wang","sequence":"additional","affiliation":[{"name":"Tianjin Key Laboratory of Food and Biotechnology, School of Biotechnology and Food Science, Tianjin University of Commerce, Tianjin 300134, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7668-6868","authenticated-orcid":true,"given":"Qiang","family":"Liu","sequence":"additional","affiliation":[{"name":"Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300192, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dexian","family":"Zhi","sequence":"additional","affiliation":[{"name":"Tianjin Key Laboratory of Food and Biotechnology, School of Biotechnology and Food Science, Tianjin University of Commerce, Tianjin 300134, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3710-3607","authenticated-orcid":true,"given":"Hui","family":"Zhao","sequence":"additional","affiliation":[{"name":"Tianjin Key Laboratory of Food and Biotechnology, School of Biotechnology and Food Science, Tianjin University of Commerce, Tianjin 300134, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2015.04.043"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pathol-011110-130246"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)60383-9"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2007.04.061"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2004.08.028"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21036"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2001.27188"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.2174\/1381612821666151029112126"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1209954"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2010.213"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2004.10.003"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1007\/s10495-005-1055-4"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1080\/21551197.2012.702534"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1007\/s10482-012-9734-y"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2006.04.003"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.5012\/bkcs.2013.34.8.2535"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-014-9863-8"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1111\/j.1745-7254.2007.00510.x"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2004.042127"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-1661-0_2"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1016\/j.fshw.2015.07.001"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2007.04.016"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1002\/hep.24281"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1207230"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbcan.2006.02.001"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2014.03.008"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1007\/s00210-014-0968-2"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1089\/jmf.2013.0179"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2012.11.040"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2012.12.023"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1007\/bf02980162"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1021\/np200001x"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2009.02.004"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1016\/s0168-8278(00)80159-2"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510300327"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2010.97"},{"key":"37","doi-asserted-by":"publisher","DOI":"10.1002\/jat.1249"},{"key":"38","doi-asserted-by":"publisher","DOI":"10.1007\/s10495-005-1877-0"},{"key":"39","doi-asserted-by":"publisher","DOI":"10.1080\/01926230701320337"},{"key":"40","doi-asserted-by":"publisher","DOI":"10.1016\/s0022-1759(02)00070-4"},{"key":"41","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1209936"},{"key":"42","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(01)00142-8"},{"key":"43","doi-asserted-by":"publisher","DOI":"10.1016\/s0891-5849(96)00327-9"},{"key":"44","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2009.04.009"},{"key":"45","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M001422200"},{"key":"46","doi-asserted-by":"publisher","DOI":"10.1016\/s0955-2863(02)00208-5"},{"key":"47","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2014.09.032"}],"container-title":["BioMed Research International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2016\/1068528.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2016\/1068528.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2016\/1068528.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,16]],"date-time":"2020-05-16T17:14:03Z","timestamp":1589649243000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/bmri\/2016\/1068528\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":47,"alternative-id":["1068528","1068528"],"URL":"https:\/\/doi.org\/10.1155\/2016\/1068528","relation":{},"ISSN":["2314-6133","2314-6141"],"issn-type":[{"value":"2314-6133","type":"print"},{"value":"2314-6141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016]]}}}