{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T17:04:12Z","timestamp":1791911052636,"version":"4.3.4"},"reference-count":72,"publisher":"Wiley","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Disease Markers"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p>Keratoconus is a degenerative disorder with progressive stromal thinning and transformation of the normal corneal architecture towards ectasia that results in decreased vision due to irregular astigmatism and irreversible tissue scarring. The pathogenesis of keratoconus still remains unclear. Hypotheses that this condition has an inflammatory etiopathogenetic component apart from the genetic and environmental factors are beginning to escalate in the research domain. This paper covers the most relevant and recent published papers regarding the biomarkers of inflammation, their signaling pathway, and the potentially new therapeutic options in keratoconus.<\/jats:p>","DOI":"10.1155\/2016\/1243819","type":"journal-article","created":{"date-parts":[[2016,8,3]],"date-time":"2016-08-03T17:00:55Z","timestamp":1470243655000},"page":"1-8","source":"Crossref","is-referenced-by-count":66,"title":["Inflammatory Biomarkers Profile as Microenvironmental Expression in Keratoconus"],"prefix":"10.1155","volume":"2016","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4201-7033","authenticated-orcid":true,"given":"Catalina","family":"Ionescu","sequence":"first","affiliation":[{"name":"Clinical Hospital of Ophthalmologic Emergencies (SCUO), Pia\u021ba Alexandru Lahovari 1, Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7274-0903","authenticated-orcid":true,"given":"Catalina Gabriela","family":"Corbu","sequence":"additional","affiliation":[{"name":"Clinical Hospital of Ophthalmologic Emergencies (SCUO), Pia\u021ba Alexandru Lahovari 1, Bucharest, Romania"},{"name":"Division of Ophthalmology, Faculty of Medicine, \u201cCarol Davila\u201d University of Medicine and Pharmacy, Bulevardul Eroii Sanitari 8, 050474 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2122-0235","authenticated-orcid":true,"given":"Cristiana","family":"Tanase","sequence":"additional","affiliation":[{"name":"Biochemistry-Proteomics Department, Victor Babes National Institute of Pathology, Sector 5, 050096 Bucharest, Romania"},{"name":"Faculty of Medicine, Titu Maiorescu University, D\u00e2mbovnicului Street 22, 040441 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Jonescu-Cuypers","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Charit\u00e9 University Hospital, Campus Benjamin Franklin, Hindenburgdamm 30, 12203 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Nicula","sequence":"additional","affiliation":[{"name":"Division of Ophthalmology, Faculty of Medicine, University of Medicine and Pharmacy \u201cIuliu Hatieganu\u201d Cluj-Napoca, Victor Babes Street 8, 400012 Cluj-Napoca, Romania"},{"name":"Clinical Emergency Hospital Cluj-Napoca, Clinicilor Street 3-5, 400006 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6421-9675","authenticated-orcid":true,"given":"Dana","family":"Dascalescu","sequence":"additional","affiliation":[{"name":"Clinical Hospital of Ophthalmologic Emergencies (SCUO), Pia\u021ba Alexandru Lahovari 1, Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9701-4104","authenticated-orcid":true,"given":"Miruna","family":"Cristea","sequence":"additional","affiliation":[{"name":"Clinical Hospital of Ophthalmologic Emergencies (SCUO), Pia\u021ba Alexandru Lahovari 1, Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liliana-Mary","family":"Voinea","sequence":"additional","affiliation":[{"name":"Division of Ophthalmology, Faculty of Medicine, \u201cCarol Davila\u201d University of Medicine and Pharmacy, Bulevardul Eroii Sanitari 8, 050474 Bucharest, Romania"},{"name":"Department of Ophthalmology, University Emergency Hospital, Splaiul Independen\u021bei 169, 050098 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6257(97)00119-7"},{"key":"2","year":"2014"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.4103\/0974-9233.75876"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1006\/exer.1996.0038"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.84.8.834"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtos.2015.04.006"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.04-0549"},{"key":"51","doi-asserted-by":"publisher","DOI":"10.1038\/eye.2015.63"},{"key":"8","year":"2013"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1038\/eye.2013.278"},{"key":"10","year":"2012"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1128\/mcb.24.1.245-257.2004"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1097\/00003226-199211000-00012"},{"key":"13","year":"2012"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-3768.2007.01142.x"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1016\/s0002-9394(02)01698-7"},{"key":"16","first-page":"25","volume":"262","year":"1996","journal-title":"Bulletin de la Soci\u00e9t\u00e9 Belge d'Ophtalmologie"},{"issue":"9","key":"17","first-page":"2441","volume":"32","year":"1991","journal-title":"Investigative Ophthalmology & Visual Science"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2013.11.010"},{"issue":"4","key":"19","first-page":"425","volume":"316","year":"1993","journal-title":"Comptes Rendus de l'Academie des Sciences-Series III"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2012.03.018"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1186\/s12953-014-0047-0"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/979748"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1111\/j.1699-0463.1995.tb01092.x"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1159\/000237126"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1038\/nrd3794"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-07-273417"},{"key":"27","year":"2000"},{"key":"28","first-page":"3","volume":"12","year":"1994","journal-title":"Stem Cells"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cdd.4401189"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2007.01.011"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1016\/s0167-4838(99)00279-4"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2008.144253"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1007\/s10792-014-9971-3"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1159\/000351626"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/9392640"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-3768.2011.02369.x"},{"key":"37","first-page":"2124","volume":"19","year":"2013","journal-title":"Molecular Vision"},{"key":"38","doi-asserted-by":"publisher","DOI":"10.1111\/cxo.12038"},{"key":"39","doi-asserted-by":"publisher","DOI":"10.1111\/cxo.12118"},{"key":"40","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0b013e31816a3591"},{"key":"41","doi-asserted-by":"publisher","DOI":"10.1097\/ICL.0b013e318273b35f"},{"key":"42","first-page":"2055","volume":"16","year":"2010","journal-title":"Molecular Vision"},{"key":"43","doi-asserted-by":"publisher","DOI":"10.1016\/j.jprot.2013.05.023"},{"key":"44","first-page":"1949","volume":"16","year":"2010","journal-title":"Molecular Vision"},{"key":"45","doi-asserted-by":"publisher","DOI":"10.1038\/sj.eye.6702692"},{"key":"46","doi-asserted-by":"publisher","DOI":"10.4103\/0301-4738.116063"},{"key":"47","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0076333"},{"key":"48","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2004.11.050"},{"key":"49","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0016437"},{"key":"50","doi-asserted-by":"publisher","DOI":"10.1097\/ico.0000000000000260"},{"key":"52","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.85.2.147"},{"key":"53","doi-asserted-by":"publisher","DOI":"10.1097\/01.ico.0000183534.22522.39"},{"key":"54","doi-asserted-by":"publisher","DOI":"10.1046\/j.1442-9071.2001.00449.x"},{"key":"55","doi-asserted-by":"publisher","DOI":"10.1097\/01.ico.0000208820.32614.00"},{"key":"56","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(03)00788-8"},{"key":"57","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.11-7732"},{"key":"58","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2003.10.014"},{"key":"59","doi-asserted-by":"publisher","DOI":"10.1038\/eye.2013.262"},{"key":"60","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2008.07.021"},{"issue":"1","key":"61","first-page":"10","volume":"26","year":"2000","journal-title":"The CLAO Journal"},{"key":"62","first-page":"1285","volume":"13","year":"2007","journal-title":"Molecular Vision"},{"key":"63","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2007.02.013"},{"key":"64","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0b013e318211401f"},{"key":"65","doi-asserted-by":"publisher","DOI":"10.1038\/eye.2014.163"},{"key":"66","doi-asserted-by":"publisher","DOI":"10.1186\/s40662-016-0033-y"},{"issue":"3","key":"67","first-page":"345","volume":"16","year":"1997","journal-title":"Cornea"},{"key":"68","doi-asserted-by":"publisher","DOI":"10.1111\/cxo.12138"},{"key":"69","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.14-14831"},{"key":"70","first-page":"577","volume":"21","year":"2015","journal-title":"Molecular Vision"},{"key":"71","doi-asserted-by":"publisher","DOI":"10.1097\/ico.0b013e318198384f"},{"key":"72","doi-asserted-by":"publisher","DOI":"10.1097\/COH.0b013e32833ed177"}],"container-title":["Disease Markers"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/dm\/2016\/1243819.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/dm\/2016\/1243819.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/dm\/2016\/1243819.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2016,8,18]],"date-time":"2016-08-18T07:46:37Z","timestamp":1471506397000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/dm\/2016\/1243819\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":72,"alternative-id":["1243819","1243819"],"URL":"https:\/\/doi.org\/10.1155\/2016\/1243819","relation":{},"ISSN":["0278-0240","1875-8630"],"issn-type":[{"value":"0278-0240","type":"print"},{"value":"1875-8630","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016]]}}}