{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T14:45:25Z","timestamp":1761489925506,"version":"3.37.3"},"reference-count":13,"publisher":"Wiley","license":[{"start":{"date-parts":[[2016,2,29]],"date-time":"2016-02-29T00:00:00Z","timestamp":1456704000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009467","name":"University of the Witwatersrand, Johannesburg","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009467","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Scholarly Research Notices"],"published-print":{"date-parts":[[2016,2,29]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. Severe hyperbilirubinaemia requiring exchange transfusion has become less common in recent years; however, kernicterus still occurs. The aim of this study was to review babies undergoing exchange transfusion for severe hyperbilirubinaemia in a Johannesburg hospital.<jats:italic>Methodology<\/jats:italic>. This was a retrospective review of babies who required exchange transfusion in both the neonatal and the paediatric wards from June 1, 2006, to December 31, 2011.<jats:italic>Results<\/jats:italic>. There were 64 patients who underwent 67 exchange transfusions. Isoimmune haemolysis (both Rh and ABO incompatibility) was the cause of jaundice in 9\/64 (14%). Most babies who underwent exchange transfusion were sick or preterm and were admitted in hospital after birth (38\/64; 59.5%); three of these babies died, but not during the exchange transfusion (3\/38; 7.9%); all three had signs suggestive of neonatal sepsis. The remaining 26 babies (40.6%) were readmitted to the paediatric wards for exchange transfusion. Six of these babies (6\/26; 23.0%) had signs of kernicterus. The most significant complication of exchange transfusion was apnoea requiring mechanical ventilation in three patients (3\/64; 4.6%).<jats:italic>Conclusion<\/jats:italic>. Despite a relatively low number of babies undergoing exchange transfusion, kernicterus still occurs and must be prevented. Proper protocols for screening and management of severe hyperbilirubinaemia need to be enforced.<\/jats:p>","DOI":"10.1155\/2016\/1268149","type":"journal-article","created":{"date-parts":[[2016,2,29]],"date-time":"2016-02-29T21:00:49Z","timestamp":1456779649000},"page":"1-5","source":"Crossref","is-referenced-by-count":11,"title":["Exchange Transfusion for Neonatal Hyperbilirubinemia in Johannesburg, South Africa, from 2006 to 2011"],"prefix":"10.1155","volume":"2016","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4985-048X","authenticated-orcid":true,"given":"Daynia E.","family":"Ballot","sequence":"first","affiliation":[{"name":"Department of Paediatrics and Child Health, University of the Witwatersrand, Private Bag Box 39, Johannesburg 2000, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gilbert","family":"Rugamba","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Child Health, University of the Witwatersrand, Private Bag Box 39, Johannesburg 2000, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"volume-title":"Kernicterus","year":"2014","key":"1"},{"doi-asserted-by":"publisher","key":"2","DOI":"10.1053\/j.semperi.2011.02.003"},{"issue":"6","key":"3","first-page":"244","volume":"6","year":"1989","journal-title":"Photodermatology"},{"issue":"5, part 1","key":"4","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1542\/peds.89.5.809","volume":"89","year":"1992","journal-title":"Pediatrics"},{"issue":"4, part 1","key":"5","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1542\/peds.94.4.558","volume":"94","year":"1994","journal-title":"Pediatrics"},{"issue":"9","key":"6","first-page":"819","volume":"96","year":"2006","journal-title":"South African Medical Journal"},{"doi-asserted-by":"publisher","key":"7","DOI":"10.1038\/jp.2008.210"},{"doi-asserted-by":"publisher","key":"8","DOI":"10.1136\/archdischild-2013-305506"},{"doi-asserted-by":"publisher","key":"9","DOI":"10.1016\/j.paed.2015.02.008"},{"doi-asserted-by":"publisher","key":"10","DOI":"10.1111\/j.1365-3156.2009.02223.x"},{"issue":"4","key":"11","doi-asserted-by":"crossref","first-page":"779","DOI":"10.4269\/ajtmh.2007.77.779","volume":"77","year":"2007","journal-title":"The American Journal of Tropical Medicine and Hygiene"},{"doi-asserted-by":"publisher","key":"12","DOI":"10.1371\/journal.pone.0117229"},{"doi-asserted-by":"publisher","key":"13","DOI":"10.1186\/s12887-015-0358-z"}],"container-title":["International Scholarly Research Notices"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/archive\/2016\/1268149.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/archive\/2016\/1268149.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/archive\/2016\/1268149.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,5]],"date-time":"2022-06-05T20:09:12Z","timestamp":1654459752000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/isrn\/2016\/1268149\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2,29]]},"references-count":13,"alternative-id":["1268149","1268149"],"URL":"https:\/\/doi.org\/10.1155\/2016\/1268149","relation":{},"ISSN":["2356-7872"],"issn-type":[{"type":"electronic","value":"2356-7872"}],"subject":[],"published":{"date-parts":[[2016,2,29]]}}}