{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T03:35:30Z","timestamp":1767065730683,"version":"3.41.2"},"reference-count":37,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,9,18]],"date-time":"2016-09-18T00:00:00Z","timestamp":1474156800000},"content-version":"vor","delay-in-days":261,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81370943","81500631"],"award-info":[{"award-number":["81370943","81500631"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["BS2015YY011","ZR2013HQ054"],"award-info":[{"award-number":["BS2015YY011","ZR2013HQ054"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:p><jats:italic>Purpose.<\/jats:italic> To investigate the effects of Corbrin Capsule (CS\u2010C\u2010Q80), a drug derived from <jats:italic>Cordyceps sinensis<\/jats:italic> (Berk.) Sacc., on autoimmune thyroid diseases (AITD). <jats:italic>Methods.<\/jats:italic> 44 Patients with Graves\u2019s disease (GD) and 56 patients with Hashimoto\u2019s thyroiditis (HT) were randomly assigned to treatment group (GD\u2010Tx and HT\u2010Tx) or control group (GD\u2010Ct and HT\u2010Ct). The control groups were given methimazole or levothyroxine only while the treatment groups were given Corbrin Capsule (2.0\u2009g\u2009tid) besides the same conventional prescriptions as control groups. Thyroid hormones, thyroid antibodies, and T lymphocyte subsets were quantified at baseline and 24 weeks posttreatment. <jats:italic>Results.<\/jats:italic> Significant drop of serum anti\u2010TPO\u2010Ab levels was observed in both GD\u2010Tx and HT\u2010Tx groups. Before treatment, GD patients had higher helper T cells compared to cytotoxic T cells, while HT patients suffered from a nearly inverted proportion of helper T\/cytotoxic T cells. There was a significant drop of the helper T\/cytotoxic T cells ratio in GD\u2010Tx to the median of the normal ranges after Corbrin treatment for 24 weeks, while that in HT\u2010Tx was elevated. <jats:italic>Conclusion.<\/jats:italic> Corbrin Capsule could restore the balance between helper T and cytotoxic T cells in both GD and HT patients with dual\u2010directional immunomodulatory effects. And it could significantly reduce the autoantibody levels in both GD and HT.<\/jats:p>","DOI":"10.1155\/2016\/1360386","type":"journal-article","created":{"date-parts":[[2016,9,18]],"date-time":"2016-09-18T21:00:31Z","timestamp":1474232431000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Dual\u2010Directional Immunomodulatory Effects of Corbrin Capsule on Autoimmune Thyroid Diseases"],"prefix":"10.1155","volume":"2016","author":[{"given":"Tianyi","family":"He","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruxing","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yiran","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenjuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinguo","family":"Hou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5271-1256","authenticated-orcid":false,"given":"Ming","family":"Dong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7670-8062","authenticated-orcid":false,"given":"Li","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,9,18]]},"reference":[{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.1556\/OH.2012.29370"},{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1530\/eje.0.1500605"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1006\/clin.1997.4412"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2014.10.016"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2015.07.009"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1211\/jpp\/61.03.0002"},{"key":"e_1_2_9_7_2","first-page":"169","article-title":"Study on effect of Cordyceps sinensis and artemisinin in preventing recurrence of lupus nephritis","volume":"22","author":"Lu L.","year":"2002","journal-title":"Chinese Journal of Integrated Traditional and Western Medicine"},{"key":"e_1_2_9_8_2","first-page":"248","article-title":"Effects of cordyceps sinensis on T lymphocyte subsets and hepatofibrosis in patients with chronic hepatitis B","volume":"25","author":"Gong H. 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