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Vitamin D may also promote<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mrow><mml:msub><mml:mrow><mml:mi mathvariant=\"normal\">T<\/mml:mi><\/mml:mrow><mml:mrow><mml:mi mathvariant=\"normal\">R<\/mml:mi><mml:mi mathvariant=\"normal\">e<\/mml:mi><mml:mi mathvariant=\"normal\">g<\/mml:mi><\/mml:mrow><\/mml:msub><\/mml:mrow><\/mml:math>cell tropism to dermal sites. In the current study, we examined the capacity of dietary vitamin D<jats:sub>3<\/jats:sub>to modulate skin inflammation and the numbers and activity of<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mrow><mml:msub><mml:mrow><mml:mi mathvariant=\"normal\">T<\/mml:mi><\/mml:mrow><mml:mrow><mml:mi mathvariant=\"normal\">R<\/mml:mi><mml:mi mathvariant=\"normal\">e<\/mml:mi><mml:mi mathvariant=\"normal\">g<\/mml:mi><\/mml:mrow><\/mml:msub><\/mml:mrow><\/mml:math>cells in skin and other sites including lungs, spleen, and blood. In female BALB\/c mice, dietary vitamin D<jats:sub>3<\/jats:sub>suppressed the effector phase of a biphasic ear swelling response induced by dinitrofluorobenzene in comparison vitamin D<jats:sub>3<\/jats:sub>-deficient female BALB\/c mice. Vitamin D<jats:sub>3<\/jats:sub>increased the percentage of<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mrow><mml:msub><mml:mrow><mml:mi mathvariant=\"normal\">T<\/mml:mi><\/mml:mrow><mml:mrow><mml:mi mathvariant=\"normal\">R<\/mml:mi><mml:mi mathvariant=\"normal\">e<\/mml:mi><mml:mi mathvariant=\"normal\">g<\/mml:mi><\/mml:mrow><\/mml:msub><\/mml:mrow><\/mml:math>(CD3+CD4+CD25+Foxp3+) cells in the skin-draining lymph nodes (SDLN). The suppressive activity of<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:mrow><mml:msub><mml:mrow><mml:mi mathvariant=\"normal\">T<\/mml:mi><\/mml:mrow><mml:mrow><mml:mi mathvariant=\"normal\">R<\/mml:mi><mml:mi mathvariant=\"normal\">e<\/mml:mi><mml:mi mathvariant=\"normal\">g<\/mml:mi><\/mml:mrow><\/mml:msub><\/mml:mrow><\/mml:math>cells in the SDLN, mesenteric lymph nodes, spleen, and blood was upregulated by vitamin D<jats:sub>3<\/jats:sub>. However, there was no difference in the expression of the naturally occurring<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\"><mml:mrow><mml:msub><mml:mrow><mml:mi mathvariant=\"normal\">T<\/mml:mi><\/mml:mrow><mml:mrow><mml:mi mathvariant=\"normal\">R<\/mml:mi><mml:mi mathvariant=\"normal\">e<\/mml:mi><mml:mi mathvariant=\"normal\">g<\/mml:mi><\/mml:mrow><\/mml:msub><\/mml:mrow><\/mml:math>cell marker, neuropilin, nor the expression of CCR4 or CCR10 (skin-tropic chemokine receptors) on<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M7\"><mml:mrow><mml:msub><mml:mrow><mml:mi mathvariant=\"normal\">T<\/mml:mi><\/mml:mrow><mml:mrow><mml:mi mathvariant=\"normal\">R<\/mml:mi><mml:mi mathvariant=\"normal\">e<\/mml:mi><mml:mi mathvariant=\"normal\">g<\/mml:mi><\/mml:mrow><\/mml:msub><\/mml:mrow><\/mml:math>cells in skin, SDLN, lungs, and airway-draining lymph nodes. These data suggest that dietary vitamin D<jats:sub>3<\/jats:sub>increased the percentages and suppressive activity of<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M8\"><mml:mrow><mml:msub><mml:mrow><mml:mi mathvariant=\"normal\">T<\/mml:mi><\/mml:mrow><mml:mrow><mml:mi mathvariant=\"normal\">R<\/mml:mi><mml:mi mathvariant=\"normal\">e<\/mml:mi><mml:mi mathvariant=\"normal\">g<\/mml:mi><\/mml:mrow><\/mml:msub><\/mml:mrow><\/mml:math>cells in the SDLN, which are poised to suppress dermal inflammation.<\/jats:p>","DOI":"10.1155\/2016\/1426503","type":"journal-article","created":{"date-parts":[[2016,9,8]],"date-time":"2016-09-08T17:02:51Z","timestamp":1473354171000},"page":"1-13","source":"Crossref","is-referenced-by-count":18,"title":["Dietary Vitamin D Increases Percentages and Function of Regulatory T Cells in the Skin-Draining Lymph Nodes and Suppresses Dermal 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