{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T15:21:42Z","timestamp":1759332102289},"reference-count":13,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Ophthalmology"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p><jats:italic>Purpose<\/jats:italic>. To evaluate corneal thickness changes during pulsed accelerated corneal cross-linking (CXL) for keratoconus using a new isotonic riboflavin formula.<jats:italic>Methods<\/jats:italic>. In this prospective, interventional, clinical study patients with grades 1-2 keratoconus (Amsler-Krumeich classification) underwent pulsed accelerated (30\u2009mW\/cm<jats:sup>2<\/jats:sup>) CXL after application of an isotonic riboflavin solution (0.1%) with HPMC for 10 minutes. Central corneal thickness (CCT) measurements were taken using ultrasound pachymetry before and after epithelial removal, after riboflavin soaking, and immediately after completion of UVA treatment.<jats:italic>Results<\/jats:italic>. Twenty eyes of 11 patients (4 males, 7 females) were enrolled. Mean patient age was<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mn mathvariant=\"normal\">26<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn mathvariant=\"normal\">3<\/mml:mn><\/mml:math>(range from 18 to 30 years). No intraoperative or postoperative complications were observed in any of the patients. Mean CCT was<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mn mathvariant=\"normal\">507<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn mathvariant=\"normal\">35<\/mml:mn><\/mml:math>\u2009<jats:italic>\u03bc<\/jats:italic>m (range: 559\u2013459\u2009<jats:italic>\u03bc<\/jats:italic>m) before and<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mn mathvariant=\"normal\">475<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn mathvariant=\"normal\">40<\/mml:mn><\/mml:math>\u2009<jats:italic>\u03bc<\/jats:italic>m (range: 535\u2013420\u2009<jats:italic>\u03bc<\/jats:italic>m) after epithelial removal (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn mathvariant=\"normal\">0.001<\/mml:mn><\/mml:math>). After 10 minutes of riboflavin instillation, there was a statistically significant decrease of CCT by 6.2% from<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:mn mathvariant=\"normal\">475<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn mathvariant=\"normal\">40<\/mml:mn><\/mml:math>\u2009<jats:italic>\u03bc<\/jats:italic>m (range: 535\u2013420\u2009<jats:italic>\u03bc<\/jats:italic>m) to<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\"><mml:mn mathvariant=\"normal\">446<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn mathvariant=\"normal\">31<\/mml:mn><\/mml:math>\u2009<jats:italic>\u03bc<\/jats:italic>m (range: 508\u2013400) (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M7\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn mathvariant=\"normal\">0.005<\/mml:mn><\/mml:math>). There was no other statistically significant change of CCT during UVA irradiation.<jats:italic>Conclusions<\/jats:italic>. A significant decrease of corneal thickness was demonstrated during the isotonic riboflavin with HPMC application while there was no significant change during the pulsed accelerated UVA irradiation.<\/jats:p>","DOI":"10.1155\/2016\/1471807","type":"journal-article","created":{"date-parts":[[2016,1,13]],"date-time":"2016-01-13T21:04:52Z","timestamp":1452719092000},"page":"1-4","source":"Crossref","is-referenced-by-count":4,"title":["Intraoperative Corneal Thickness Changes during Pulsed Accelerated Corneal Cross-Linking Using Isotonic Riboflavin with HPMC"],"prefix":"10.1155","volume":"2016","author":[{"given":"Ahmed M.","family":"Sherif","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Faculty of Medicine, Cairo University, Cairo 11519, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nihal A.","family":"El-Gheriany","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Faculty of Medicine, Cairo University, Cairo 11519, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yehia M.","family":"Salah El-Din","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Faculty of Medicine, Cairo University, Cairo 11519, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lamiaa S.","family":"Aly","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Faculty of Medicine, Cairo University, Cairo 11519, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amr A.","family":"Osman","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Faculty of Medicine, Cairo University, Cairo 11519, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael A.","family":"Grentzelos","sequence":"additional","affiliation":[{"name":"Vardinoyiannion Eye Institute of Crete (VEIC), Faculty of Medicine, University of Crete, Heraklion, 71003 Crete, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George D.","family":"Kymionis","sequence":"additional","affiliation":[{"name":"Vardinoyiannion Eye Institute of Crete (VEIC), Faculty of Medicine, University of Crete, Heraklion, 71003 Crete, Greece"},{"name":"Bascom Palmer Eye Institute, University of Miami, Miller School of Medicine, Miami, FL 33136, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"98","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/s0002-9394(02)02220-1"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1097\/ico.0000000000000248"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1097\/01.icu.0000233954.86723.25"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2012.06.005"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1097\/ico.0b013e31823cbeb1"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2009.09.018"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2014.02.042"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.5301\/ejo.5000360"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2010.06.002"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2013.08.060"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.3109\/15569527.2013.793700"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0000000000000249"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1097\/ico.0000000000000188"}],"container-title":["Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/joph\/2016\/1471807.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/joph\/2016\/1471807.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/joph\/2016\/1471807.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2016,7,26]],"date-time":"2016-07-26T12:39:06Z","timestamp":1469536746000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/joph\/2016\/1471807\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":13,"alternative-id":["1471807","1471807"],"URL":"https:\/\/doi.org\/10.1155\/2016\/1471807","relation":{},"ISSN":["2090-004X","2090-0058"],"issn-type":[{"value":"2090-004X","type":"print"},{"value":"2090-0058","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016]]}}}