{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,22]],"date-time":"2024-08-22T23:40:40Z","timestamp":1724370040799},"reference-count":27,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Disease Markers"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p><jats:italic>Objective<\/jats:italic>. To determine the prognostic significance of beta2 microglobulin (<jats:italic>\u03b2<\/jats:italic><jats:sub>2<\/jats:sub>-m) concentrations in patients with hemophagocytic lymphohistiocytosis (HLH), a rare disorder caused by pathologic activation of the immune system.<jats:italic>Patients and Methods<\/jats:italic>. The study population consisted of 74 patients diagnosed with HLH and 35 healthy controls. Serum<jats:italic>\u03b2<\/jats:italic><jats:sub>2<\/jats:sub>-m levels were measured using a latex agglutination photometric immunoassay.<jats:italic>Results<\/jats:italic>. Median serum<jats:italic>\u03b2<\/jats:italic><jats:sub>2<\/jats:sub>-m levels were significantly higher in HLH patients than in healthy controls (4.05 versus 1.5\u2009mg\/L;<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn fontstyle=\"italic\">0.001<\/mml:mn><\/mml:math>) and were significantly higher in patients with lymphoma associated hemophagocytic syndrome (LAHS) than in patients with benign disease-associated HLH (4.2 versus 3.3\u2009mg\/L;<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn fontstyle=\"italic\">0.001<\/mml:mn><\/mml:math>). Higher serum<jats:italic>\u03b2<\/jats:italic><jats:sub>2<\/jats:sub>-m levels were positively correlated with LAHS (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0.005<\/mml:mn><\/mml:math>), abnormal lactate dehydrogenase concentrations (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0.009<\/mml:mn><\/mml:math>), and hypoalbuminemia (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0.003<\/mml:mn><\/mml:math>). ROC analysis showed that overall survival (OS) was significantly shorter in LAHS patients with serum<jats:italic>\u03b2<\/jats:italic><jats:sub>2<\/jats:sub>-m levels \u22654.03\u2009mg\/L compared to &lt;4.03\u2009mg\/L (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn fontstyle=\"italic\">0.001<\/mml:mn><\/mml:math>). Moreover, multivariate analysis showed that serum<jats:italic>\u03b2<\/jats:italic><jats:sub>2<\/jats:sub>-m level was an independent prognostic of OS (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M7\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0.0<\/mml:mn><mml:mn fontstyle=\"italic\">34<\/mml:mn><\/mml:math>) in patients with LAHS.<jats:italic>Conclusion<\/jats:italic>. High serum<jats:italic>\u03b2<\/jats:italic><jats:sub>2<\/jats:sub>-m levels and LAHS were associated with markedly poorer OS in patients with HLH. Serum<jats:italic>\u03b2<\/jats:italic><jats:sub>2<\/jats:sub>-m concentration was a powerful and independent prognostic factor for OS in patients with LAHS.<\/jats:p>","DOI":"10.1155\/2016\/1523959","type":"journal-article","created":{"date-parts":[[2016,3,27]],"date-time":"2016-03-27T17:00:30Z","timestamp":1459098030000},"page":"1-6","source":"Crossref","is-referenced-by-count":14,"title":["The Prognostic Significance of Beta2 Microglobulin in Patients with Hemophagocytic Lymphohistiocytosis"],"prefix":"10.1155","volume":"2016","author":[{"given":"Tiantong","family":"Jiang","sequence":"first","affiliation":[{"name":"Department of Cardiology, Beijing University of Chinese Medicine Third Affiliated Hospital, Beijing 100029, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiurong","family":"Ding","sequence":"additional","affiliation":[{"name":"Departments of Clinical Laboratory, Beijing Youan Hospital, Capital Medical University, Beijing 100069, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weixing","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Beijing University of Chinese Medicine Third Affiliated Hospital, Beijing 100029, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"98","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/j.blre.2007.05.001"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1309\/ajcp4zdkj4icouat"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1186\/ar3843"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1532\/ijh97.07012"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2010.551153"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdq363"},{"issue":"4","key":"7","first-page":"3049","volume":"21","year":"2001","journal-title":"Anticancer Research"},{"issue":"7","key":"8","first-page":"701","volume":"87","year":"2002","journal-title":"Haematologica"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1001\/archinternmed.2007.64"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19950401)75:7<1700::AID-CNCR2820750722>3.0.CO;2-D"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.21039"},{"key":"12","year":"2008"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1309\/ajcpo46gfkgnxcbr"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2013.12.012"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.5045\/br.2014.49.3.148"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2008.11.001"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-012-1434-1"},{"issue":"1","key":"18","first-page":"13","volume":"85","year":"1990","journal-title":"Medizinische Klinik"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1097\/00000421-200302000-00001"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2005.01.1825"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2005.07.155"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.10998"},{"issue":"10","key":"23","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.1200\/JCO.1989.7.10.1518","volume":"7","year":"1989","journal-title":"Journal of Clinical Oncology"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910400107"},{"issue":"8","key":"25","first-page":"2744","volume":"94","year":"1999","journal-title":"Blood"},{"issue":"11","key":"26","first-page":"4414","volume":"61","year":"2001","journal-title":"Cancer Research"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2011.02501.x"}],"container-title":["Disease Markers"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/dm\/2016\/1523959.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/dm\/2016\/1523959.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/dm\/2016\/1523959.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,24]],"date-time":"2017-06-24T05:22:58Z","timestamp":1498281778000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/dm\/2016\/1523959\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":27,"alternative-id":["1523959","1523959"],"URL":"https:\/\/doi.org\/10.1155\/2016\/1523959","relation":{},"ISSN":["0278-0240","1875-8630"],"issn-type":[{"value":"0278-0240","type":"print"},{"value":"1875-8630","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016]]}}}