{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T04:45:11Z","timestamp":1791521111063,"version":"4.3.4"},"reference-count":25,"publisher":"Wiley","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008322","name":"CSL Behring","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008322","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Biotest AG, Langen"},{"name":"Bayer Vital, Leverkusen"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p><jats:italic>Objectives<\/jats:italic>. To investigate self-reported health-related quality of life (HrQoL) in children and adolescents with chronic medical conditions compared with siblings\/peers.<jats:italic>Methods<\/jats:italic>. Group 1 (6 treatment centers) consisted of 74 children\/adolescents aged 8\u201316 years with hereditary bleeding disorders (HBD), 12 siblings, and 34 peers. Group 2 (one treatment center) consisted of 70 children\/adolescents with stroke\/transient ischemic attack, 14 siblings, and 72 peers. HrQoL was assessed with the \u201crevised KINDer Lebensqualit\u00e4tsfragebogen\u201d (KINDL-R) questionnaire. Multivariate analyses within groups were done by one-way ANOVA and post hoc pairwise single comparisons by Student\u2019s<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mrow><mml:mi>t<\/mml:mi><\/mml:mrow><\/mml:math>-tests. Adjusted pairwise comparisons were done by hierarchical linear regressions with individuals nested within treatment centers (group 1) and by linear regressions (group 2), respectively.<jats:italic>Results<\/jats:italic>. No differences were found in multivariate analyses of self-reported HrQoL in group 1, while in group 2 differences occurred in overall wellbeing and all subdimensions. These differences were due to differences between patients and peers. After adjusting for age, gender, number of siblings, and treatment center these differences persisted regarding self-worth (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mo>.<\/mml:mo><mml:mn fontstyle=\"italic\">0040<\/mml:mn><\/mml:math>) and friend-related wellbeing (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>p<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mo>.<\/mml:mo><mml:mn fontstyle=\"italic\">001<\/mml:mn><\/mml:math>).<jats:italic>Conclusions<\/jats:italic>. In children with HBD, HrQoL was comparable to siblings and peers. In children with stroke\/TIA HrQoL was comparable to siblings while peers, independently of relevant confounder, showed better self-worth and friend-related wellbeing.<\/jats:p>","DOI":"10.1155\/2016\/1579428","type":"journal-article","created":{"date-parts":[[2016,5,15]],"date-time":"2016-05-15T21:00:32Z","timestamp":1463346032000},"page":"1-8","source":"Crossref","is-referenced-by-count":12,"title":["Health-Related Quality of Life in Children and Adolescents with Hereditary Bleeding Disorders and in Children and Adolescents with Stroke: Cross-Sectional Comparison to Siblings and Peers"],"prefix":"10.1155","volume":"2016","author":[{"given":"Bruno","family":"Neuner","sequence":"first","affiliation":[{"name":"Department of Anesthesiology and Intensive Care Medicine, Charit\u00e9-Universitaetsmedizin Berlin, Campus Charit\u00e9 Mitte and Campus Virchow-Klinikum, 10117 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvia","family":"von Mackensen","sequence":"additional","affiliation":[{"name":"Institute for Medical Psychology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne","family":"Holzhauer","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology\/Oncology, Charit\u00e9-Universitaetsmedizin Berlin, Campus Virchow-Klinikum, 13353 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Funk","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology\/Oncology, Charit\u00e9-Universitaetsmedizin Berlin, Campus Virchow-Klinikum, 13353 Berlin, Germany"},{"name":"Working Group Cardiovascular Magnetic Resonance, Experimental und Clinical Research Center (ECRC), Charit\u00e9-Universitaetsmedizin Berlin, Campus Buch, 13125 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Klamroth","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Angiology and Clotting Disorders, Haemophilia Treatment Centre, Vivantes Clinic Friedrichshain, 10249 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin","family":"Kurnik","sequence":"additional","affiliation":[{"name":"Pediatric Thrombosis and Hemostasis Unit, Dr. von Hauner Children\u2019s Hospital, Medical Center of the University of Munich, 80337 Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Kr\u00fcmpel","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology\/Oncology, University of M\u00fcnster, 48149 M\u00fcnster, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Halimeh","sequence":"additional","affiliation":[{"name":"Coagulation Centre 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