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There are two types of FSGS, primary (idiopathic) and secondary forms. Secondary FSGS shows less severe clinical features compared to those of the primary one. However, secondary FSGS has an important clinical significance because a variety of renal diseases progress to ESRD thorough the form of secondary FSGS. The defining feature of FSGS is proteinuria. The key event of FSGS is podocyte injury which is caused by multiple factors. Unanswered questions about how these factors act on podocytes to cause secondary FSGS are various and ill-defined. In this review, we provide brief overview and new insights into FSGS, podocyte injury, and their potential linkage suggesting clues to answer for treatment of the disease.<\/jats:p>","DOI":"10.1155\/2016\/1630365","type":"journal-article","created":{"date-parts":[[2016,3,21]],"date-time":"2016-03-21T22:39:44Z","timestamp":1458599984000},"page":"1-7","source":"Crossref","is-referenced-by-count":17,"title":["Secondary Focal Segmental Glomerulosclerosis: From Podocyte Injury to Glomerulosclerosis"],"prefix":"10.1155","volume":"2016","author":[{"given":"Jae Seok","family":"Kim","sequence":"first","affiliation":[{"name":"Division of Nephrology, Department of Internal Medicine, Yonsei University Wonju College of Medicine, Wonju 220-701, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byoung Geun","family":"Han","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Internal Medicine, Yonsei University Wonju College of Medicine, Wonju 220-701, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung Ok","family":"Choi","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Internal Medicine, Yonsei University Wonju College of Medicine, Wonju 220-701, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung-Kuy","family":"Cha","sequence":"additional","affiliation":[{"name":"Departments of Physiology and Global Medical Science, Yonsei University Wonju College of Medicine, Wonju 220-701, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1056\/nejmra1106556"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2411"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa1506362"},{"issue":"5","key":"4","first-page":"403","volume":"150","year":"2014","journal-title":"Gaceta Medica de Mexico"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2010.10.007"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00020.2002"},{"issue":"5","key":"7","first-page":"673","volume":"59","year":"1988","journal-title":"Laboratory Investigation"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00290.2001"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.2174\/13892029113146660014"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00196.2005"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASN.0000039661.06947.FD"},{"issue":"3","key":"12","first-page":"571","volume":"141","year":"1992","journal-title":"American Journal of Pathology"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1097\/00041552-200107000-00009"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1994.47"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2014030278"},{"issue":"4","key":"16","first-page":"1283","volume":"148","year":"1996","journal-title":"American Journal of Pathology"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200112539"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1126\/science.1145209"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfr771"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfq121"},{"issue":"3","key":"21","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1681\/ASN.V123413","volume":"12","year":"2001","journal-title":"Journal of the American Society of Nephrology"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1681\/asn.2005010055"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1172\/JCI119163"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2002.00269.x"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2001.060003957.x"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1985.225"},{"issue":"45","key":"27","first-page":"S58","year":"1994","journal-title":"Kidney International. 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