{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T21:15:29Z","timestamp":1788902129041,"version":"build-2803163510"},"reference-count":46,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Comisi\u00f3n de Operaci\u00f3n y Fomento de Actividades Acad\u00e9micas del IPN"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p>The RABVG ectodomain is a homotrimer, and trimers are often called spikes. They are responsible for the attachment of the virus through the interaction with nicotinic acetylcholine receptors, neural cell adhesion molecule (NCAM), and the p75 neurotrophin receptor (p75NTR). This makes them relevant in viral pathogenesis. The antigenic structure differs significantly between the trimers and monomers. Surfaces rich in hydrophobic amino acids are important for trimer stabilization in which the C-terminal of the ectodomain plays an important role; to understand these interactions between the G proteins, a mechanistic study of their functions was performed with a molecular model of G protein in its trimeric form. This verified its 3D conformation. The molecular modeling of G protein was performed by a I-TASSER server and was evaluated via a Rachamandran plot and ERRAT program obtained 84.64% and 89.9% of the residues in the favorable regions and overall quality factor, respectively. The molecular dynamics simulations were carried out on RABVG trimer at 310\u2009K. From these theoretical studies, we retrieved the RMSD values from C<jats:italic>\u03b1<\/jats:italic>atoms to assess stability. Preliminary model of G protein of rabies virus stable at 12\u2009ns with molecular dynamics was obtained.<\/jats:p>","DOI":"10.1155\/2016\/1674580","type":"journal-article","created":{"date-parts":[[2016,4,24]],"date-time":"2016-04-24T21:00:38Z","timestamp":1461531638000},"page":"1-11","source":"Crossref","is-referenced-by-count":20,"title":["Predicted 3D Model of the Rabies Virus Glycoprotein Trimer"],"prefix":"10.1155","volume":"2016","author":[{"given":"Bastida-Gonz\u00e1lez","family":"Fernando","sequence":"first","affiliation":[{"name":"Laboratorio de Medicina Traslacional, Escuela Superior de Medicina, Instituto Polit\u00e9cnico Nacional, Plan de San Luis y D\u00edaz Mir\u00f3n s\/n, Santo Tomas, Miguel Hidalgo, 11340 Ciudad de M\u00e9xico, DF, Mexico"},{"name":"Laboratorio de Biolog\u00eda Molecular, Laboratorio Estatal de Salud P\u00fablica del Estado de M\u00e9xico, Paseo Tollocan s\/n, La moderna de la cruz, 50180 Toluca, MEX, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celaya-Trejo","family":"Yersin","sequence":"additional","affiliation":[{"name":"Laboratorio de Medicina Traslacional, Escuela Superior de Medicina, Instituto Polit\u00e9cnico Nacional, Plan de San Luis y D\u00edaz Mir\u00f3n s\/n, Santo Tomas, Miguel Hidalgo, 11340 Ciudad de M\u00e9xico, DF, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Correa-Basurto","family":"Jos\u00e9","sequence":"additional","affiliation":[{"name":"Laboratorio de Modelado Molecular y Bioinform\u00e1tica, Escuela Superior de Medicina, Instituto Polit\u00e9cnico Nacional, Plan de San Luis y D\u00edaz Mir\u00f3n s\/n, Santo Tomas, Miguel Hidalgo, 11340 Ciudad de M\u00e9xico, DF, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z\u00e1rate-Segura","family":"Paola","sequence":"additional","affiliation":[{"name":"Laboratorio de Medicina Traslacional, Escuela Superior de Medicina, Instituto Polit\u00e9cnico Nacional, Plan de San Luis y D\u00edaz Mir\u00f3n s\/n, Santo Tomas, Miguel Hidalgo, 11340 Ciudad de M\u00e9xico, DF, Mexico"},{"name":"Departamento de Bioprocesos, Unidad Profesional Interdisciplinaria de Biotecnolog\u00eda, Instituto Polit\u00e9cnico Nacional, Avenida Acueducto de Guadalupe s\/n, Ticoman, Gustavo A. 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