{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T05:18:20Z","timestamp":1761110300693,"version":"3.37.3"},"reference-count":26,"publisher":"Wiley","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Ophthalmology"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p><jats:italic>Aim of Work<\/jats:italic>. To evaluate the efficacy of intravitreal methotrexate (MTX) compared to retrobulbar triamcinolone acetonide (TAA), in controlling posterior segment involvement and inducing remissions among Beh\u00e7et\u2019s disease (BD) patients.<jats:italic>Study Design<\/jats:italic>. This is a cross-sectional nonrandomized comparative study.<jats:italic>Patients and Methods<\/jats:italic>. 31 adult BD male patients with a mean disease duration of 5.45 years who presented with bilateral posterior segment involvement were included. Each patient received intravitreal injection of 400\u2009<jats:italic>\u03bc<\/jats:italic>g\/0.1\u2009mL (MTX) for the right eye (Group A) and 1\u2009mL of retrobulbar 40\u2009mg\/mL TAA for the left eye (Group B).<jats:italic>Results<\/jats:italic>. 90% of eyes showed complete improvement of anterior chamber reaction, whereas an improvement in vitreous activity in 77% with no significant differences between both groups (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>p<\/mml:mi><mml:mo>\u2264<\/mml:mo><mml:mn fontstyle=\"italic\">0.1<\/mml:mn><\/mml:math>). BCVA improved in 77.4% eyes (Group A) compared to 87.1% (Group B) (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>p<\/mml:mi><mml:mo>\u2264<\/mml:mo><mml:mn fontstyle=\"italic\">0.4<\/mml:mn><\/mml:math>). Relapses were noted in 11 eyes (35.5%), in group A, with the mean duration of remission being 19.1 weeks \u00b1 2.13 compared to<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mn fontstyle=\"italic\">7.35<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn fontstyle=\"italic\">2.8<\/mml:mn><\/mml:math>in 20 eyes (64.5%) in group B (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mi>p<\/mml:mi><mml:mo>\u2264<\/mml:mo><mml:mn fontstyle=\"italic\">0.1<\/mml:mn><\/mml:math>).<jats:italic>Conclusion<\/jats:italic>. No statistical differences were found between both treatment modalities; however, based on clinical observations, intravitreal MTX may ensure better control of inflammatory reaction and may encourage longer remission as compared to retrobulbar TAA in BD patients.<\/jats:p>","DOI":"10.1155\/2016\/1678495","type":"journal-article","created":{"date-parts":[[2016,12,13]],"date-time":"2016-12-13T21:01:10Z","timestamp":1481662870000},"page":"1-5","source":"Crossref","is-referenced-by-count":17,"title":["The Effectiveness of Intraocular Methotrexate in the Treatment of Posterior Uveitis in Beh\u00e7et\u2019s Disease Patients Compared to Retrobulbar Steroids Injection"],"prefix":"10.1155","volume":"2016","author":[{"given":"Hossam El Din Mohamed","family":"Khalil","sequence":"first","affiliation":[{"name":"Beni Suef University, Beni Suef, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2647-5883","authenticated-orcid":true,"given":"Heba 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