{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T21:00:48Z","timestamp":1792011648590,"version":"4.4.0"},"reference-count":21,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p>In our retrospective study we evaluated the efficacy of an improved amniotic membrane (AM) roll-in filling technique (AMR) combined with multilayer amniotic membrane cover to treat corneal perforation and included 46 cornea perforations \u2264 3\u2009mm in diameter treated with AMR and 20% C<jats:sub>3<\/jats:sub>F<jats:sub>8<\/jats:sub>mixed gas filling of the anterior chamber. Anterior chamber depth, aqueous leakage, bubble maintenance time, and cornea morphology were monitored after each operation. The mean diameter of corneal perforation was<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mn fontstyle=\"italic\">1.60<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn fontstyle=\"italic\">0.55<\/mml:mn><\/mml:math>\u2009mm (range 0.5\u20133) and the success rate of the AMR method for corneal perforation reconstruction was 100% after a single operation. Anterior chamber depth was normally reconstructed without AMR break-off, aqueous leak, or other complications. The mean time of the C<jats:sub>3<\/jats:sub>F<jats:sub>8<\/jats:sub>gas bubble in the anterior chamber was<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mn fontstyle=\"italic\">8.6<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn fontstyle=\"italic\">2.0<\/mml:mn><\/mml:math>days (range 4\u201312). At the last follow-up, all patients\u2019 visual acuity was improved to varying degrees. The mean follow-up time was<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mn fontstyle=\"italic\">11.0<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn fontstyle=\"italic\">5.6<\/mml:mn><\/mml:math>months (range 3\u201336). The AMR plugging combined with multilayer AM cover is a secure and easy intervention, which led to 100% success in our study. Various perforations ranging from trauma to infection can be treated with AMR, which is especially practical in those countries where donor cornea availability is limited.<\/jats:p>","DOI":"10.1155\/2016\/1693815","type":"journal-article","created":{"date-parts":[[2016,5,23]],"date-time":"2016-05-23T17:01:00Z","timestamp":1464022860000},"page":"1-8","source":"Crossref","is-referenced-by-count":28,"title":["Improvement of Amniotic Membrane Method for the Treatment of Corneal Perforation"],"prefix":"10.1155","volume":"2016","author":[{"given":"Junhua","family":"Fan","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, The 180th Hospital of PLA, Quanzhou, Fujian 362000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meihua","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, The 180th Hospital of PLA, Quanzhou, Fujian 362000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fulu","family":"Zhong","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, The 180th Hospital of PLA, Quanzhou, Fujian 362000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"98","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/j.survophthal.2011.06.003"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.3109\/08820139.2014.910024"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(14)70125-4"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1974.01360030022006"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1016\/S0143-4004(99)80034-4"},{"key":"6","volume":"39, article s428","year":"1998","journal-title":"Investigative Ophthalmology & Visual Science"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(00)00825-4"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1006\/exer.1999.0794"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(99)90444-X"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.85.12.1455"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1016\/s0161-6420(01)01032-6"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1097\/01.ico.0000121709.58571.12"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1097\/01.ico.0000151547.08113.d1"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0b013e3181861c54"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1097\/ico.0b013e31820ce80f"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1186\/1752-1947-1-28"},{"key":"17","first-page":"694","volume":"32","year":"2007","journal-title":"Medical Journal of Chinese People's Liberation Army"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1097\/00003226-200205000-00001"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1097\/00003226-200005000-00018"},{"issue":"9","key":"20","first-page":"2506","volume":"41","year":"2000","journal-title":"Investigative Ophthalmology and Visual Science"},{"issue":"12","key":"21","first-page":"1409","volume":"27","year":"2009","journal-title":"Chinese Journal of Practical Ophthalmology"}],"container-title":["BioMed Research International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2016\/1693815.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2016\/1693815.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2016\/1693815.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2016,7,26]],"date-time":"2016-07-26T08:55:32Z","timestamp":1469523332000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/bmri\/2016\/1693815\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":21,"alternative-id":["1693815","1693815"],"URL":"https:\/\/doi.org\/10.1155\/2016\/1693815","relation":{},"ISSN":["2314-6133","2314-6141"],"issn-type":[{"value":"2314-6133","type":"print"},{"value":"2314-6141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016]]}}}