{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T19:02:43Z","timestamp":1740164563984,"version":"3.37.3"},"reference-count":18,"publisher":"Wiley","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Obstetrics and Gynecology"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p>Primary vulvar adenocarcinomas are very rare. We describe the rare case of primary vulvar apocrine adenocarcinoma, a histologically rare subtype of vulvar adenocarcinoma. A 57-year-old Japanese woman presented with an enlarging vulvar mass. A dark-red, hemorrhagic, ulcerated tumor was on the right side of the anterior labial commissure measuring approximately<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mn fontstyle=\"italic\">3.5<\/mml:mn><mml:mo>\u00d7<\/mml:mo><mml:mn fontstyle=\"italic\">3.5<\/mml:mn><\/mml:math>\u2009cm. Preoperative biopsy showed poorly differentiated carcinoma with partial differentiation to adenocarcinoma. Systemic examination revealed lymph node metastases in both inguinal regions and no other primary source. We performed radical vulvectomy and bilateral inguinal and pelvic lymphadenectomy. Histopathologic diagnosis was apocrine adenocarcinoma of the vulva with inguinal lymph node metastases, pT1bN2bM0. Surgical margins were negative. The patient received no adjuvant chemotherapy or radiation. Inguinal lymph node recurrence occurred after six months. Reresection and adjuvant tomotherapy were performed. After a further 12 months of observation, no rerecurrence was observed. The patient is now on follow-up.<\/jats:p>","DOI":"10.1155\/2016\/1712404","type":"journal-article","created":{"date-parts":[[2016,9,7]],"date-time":"2016-09-07T17:04:48Z","timestamp":1473267888000},"page":"1-4","source":"Crossref","is-referenced-by-count":0,"title":["Apocrine Adenocarcinoma of the Vulva: A Case Report and Review of the Literature"],"prefix":"10.1155","volume":"2016","author":[{"given":"Kohei","family":"Aoyama","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, North Medical Center, Kyoto Prefectural University of Medicine, Kyoto, Japan"},{"name":"Department of Obstetrics and Gynecology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9838-0627","authenticated-orcid":true,"given":"Hiroshi","family":"Matsushima","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, 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