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To identify host response to influenza A and B viruses on A549 and MDCK II cells at low and high MOIs, expressions of MxA and caspases 3, 8, and 9 and BAD, TNF<jats:italic>\u03b1<\/jats:italic>, and I<jats:italic>\u03ba<\/jats:italic>B<jats:italic>\u03b1<\/jats:italic>genes were measured in the cells supernatants. H1N1 and H3N2 prefer to initially enhance the intrinsic pathway, determined by higher caspase 9 activity in MDCK II cells compared to caspase 8 activity and vice versa in A549 cells at different MOIs, while INF B prefers extrinsic pathway in A549 cells according to significant low or undetectable caspase 9 activity and high activity of caspase 8 but also can induce intrinsic pathway in MDCK II cells as determined by significant low or undetectable activity of caspase 8 and high caspase 9 activity at different MOIs; the considerable MxA expression was found in influenza A and B viruses infected A549 and MDCK II cells at low MOIs. In conclusion, influenza A and B viruses induced extrinsic and intrinsic apoptosis in parallel, and the induction was associated with viral infection in a dose dependent manner.<\/jats:p>","DOI":"10.1155\/2016\/1738237","type":"journal-article","created":{"date-parts":[[2016,3,2]],"date-time":"2016-03-02T21:00:35Z","timestamp":1456952435000},"page":"1-14","source":"Crossref","is-referenced-by-count":16,"title":["Influenza A Virus and Influenza B Virus Can Induce Apoptosis via Intrinsic or Extrinsic Pathways and Also via NF-<i>\u03ba<\/i>B in a Time and Dose Dependent Manner"],"prefix":"10.1155","volume":"2016","author":[{"given":"Ibrahim","family":"El-Sayed","sequence":"first","affiliation":[{"name":"Genetic Engineering and Biotechnology Research Institute (GEBRI), University of Sadat City, Sadat City 32897, 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