{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:48:52Z","timestamp":1787017732374,"version":"build-2736575974"},"reference-count":32,"publisher":"Wiley","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Diabetes Research"],"published-print":{"date-parts":[[2016]]},"abstract":"\n Objective.<\/jats:italic>\n To investigate changes in serum 25(OH)VD\n 3<\/jats:sub>\n , HIF-1\n \u03b1<\/jats:italic>\n , VEGF, vWf, IGF-1, and their correlation in type 2 diabetes patients at different stages of diabetic kidney disease (DKD).\n Methods.<\/jats:italic>\n 502 type 2 diabetes patients were divided into three groups: Normoalbuminuric group (201 patients), Microalbuminuric group (171 patients), and Macroalbuminuric group (130 patients). Serum 25-hydroxyvitamin D\n 3<\/jats:sub>\n [25(OH)VD\n 3<\/jats:sub>\n ] was measured by chemiluminescence. Serum hypoxia-inducible factor-1\n \u03b1<\/jats:italic>\n (HIF-1\n \u03b1<\/jats:italic>\n ), vascular endothelial growth factor (VEGF), von Willebrand factor (vWf), and insulin-like growth factor-1 (IGF-1) were determined by enzyme-linked immunosorbent assay. We detected the aforementioned serum factors in all cases and 224 control subjects.\n Results.<\/jats:italic>\n Serum HIF-1\n \u03b1<\/jats:italic>\n , VEGF, vWf, and IGF-1 in type 2 diabetes patients were significantly higher than those in the control group and increased with the increase of Ln(ACR), respectively (\n \n P<\/mml:mi>\n <<\/mml:mo>\n 0.001<\/mml:mn>\n <\/mml:math>\n ). Serum 25(OH)VD\n 3<\/jats:sub>\n was significantly lower in type 2 diabetes patients and decreased with the increase of Ln(ACR) (\n \n P<\/mml:mi>\n <<\/mml:mo>\n 0.001<\/mml:mn>\n <\/mml:math>\n ). Ln(ACR) was positively correlated with duration, HbA1c, Scr, BUN, TC, LDL, TG, UA, HIF-1\n \u03b1<\/jats:italic>\n , VEGF, IGF-1, vWf, and Fg and negatively correlated with 25(OH)VD\n 3<\/jats:sub>\n and eGFR.\n Conclusion<\/jats:italic>\n . Serum HIF-1\n \u03b1<\/jats:italic>\n , VEGF, vWf, and IGF-1 may be involved in DKD process through inflammation, angiogenesis, and endothelial injury. Serum 25(OH)VD\n 3<\/jats:sub>\n may have protective effects on DKD partly by inhibiting inflammation, abnormal angiogenesis, and vascular endothelial dysfunction.\n <\/jats:p>","DOI":"10.1155\/2016\/1925424","type":"journal-article","created":{"date-parts":[[2016,3,16]],"date-time":"2016-03-16T17:02:16Z","timestamp":1458147736000},"page":"1-7","source":"Crossref","is-referenced-by-count":68,"title":["Levels of Serum 25(OH)VD\n 3<\/sub>\n , HIF-1\n \u03b1<\/i>\n , VEGF, vWf, and IGF-1 and Their Correlation in Type 2 Diabetes Patients with Different Urine Albumin Creatinine Ratio"],"prefix":"10.1155","volume":"2016","author":[{"given":"Ying","family":"Shao","sequence":"first","affiliation":[{"name":"Department of Endocrinology, First Affiliated Hospital of China Medical University, Shenyang, Liaoning 110001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuan","family":"Lv","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, First Affiliated Hospital of China Medical University, Shenyang, Liaoning 110001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, First Affiliated Hospital of China Medical University, Shenyang, Liaoning 110001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuyue","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, First Affiliated Hospital of China Medical University, Shenyang, Liaoning 110001, 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