{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T05:42:20Z","timestamp":1760161340425},"reference-count":14,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Nephrology"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. Acute interstitial nephritis (AIN) is a frequent cause of Acute Kidney Injury (AKI). Drug hypersensitivity is the most common etiology and the list of drugs that can induce AIN is not exhaustive yet.<jats:italic>Case Report<\/jats:italic>. Here, we describe the case of a 43-year-old man who was treated with nifedipine (Adalate\u00ae) for Raynaud\u2019s syndrome. After nifedipine introduction, serum creatininemia progressively increased from 91 to 188\u2009<jats:italic>\u03bc<\/jats:italic>mol\/L in a few months and AKI was diagnosed. Laboratory work-up results indicated the presence of tubular proteinuria and nonspecific inflammatory syndrome. Histological analysis found granulomatous interstitial nephropathy without necrosis in 20% of the kidney biopsy without immunofluorescent deposit. Nifedipine was stopped and corticosteroid treatment was started with a rapid but incomplete reduction of serum creatininemia level to 106\u2009<jats:italic>\u03bc<\/jats:italic>mol\/L.<jats:italic>Conclusion<\/jats:italic>. This is the first case of AIN caused by nifedipine.<\/jats:p>","DOI":"10.1155\/2016\/1971465","type":"journal-article","created":{"date-parts":[[2016,2,3]],"date-time":"2016-02-03T16:02:04Z","timestamp":1454515324000},"page":"1-3","source":"Crossref","is-referenced-by-count":4,"title":["Drug-Induced Acute Interstitial Nephritis with Nifedipine"],"prefix":"10.1155","volume":"2016","author":[{"given":"L\u00e9onard","family":"Golbin","sequence":"first","affiliation":[{"name":"CHU de Rennes, Service de N\u00e9phrologie, 35033 Rennes, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thibault","family":"Dolley-Hitze","sequence":"additional","affiliation":[{"name":"CHU de Rennes, Service de N\u00e9phrologie, 35033 Rennes, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nolwenn","family":"Lorcy","sequence":"additional","affiliation":[{"name":"CHU de Rennes, Service de N\u00e9phrologie, 35033 Rennes, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathalie","family":"Rioux-Leclercq","sequence":"additional","affiliation":[{"name":"CNRS UMR 6290, \u00c9quipe Kyca, 35043 Rennes, France"},{"name":"CHU de Rennes, Service d\u2019Anatomie et Cytologie Pathologiques, 35033 Rennes, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C\u00e9cile","family":"Vigneau","sequence":"additional","affiliation":[{"name":"CHU de Rennes, Service de N\u00e9phrologie, 35033 Rennes, France"},{"name":"CNRS UMR 6290, \u00c9quipe Kyca, 35043 Rennes, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"98","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/s0272-6386(00)70196-x"},{"issue":"12","key":"2","first-page":"2527","volume":"67","year":"2003","journal-title":"American Family Physician"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2010.71"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1056\/nejm196812052792302"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2010.89"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2014.04.027"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfr500"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1159\/000045688"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(84)90540-0"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.01330213"},{"key":"11","first-page":"646","volume":"20","year":"1983","journal-title":"Proceedings of the European Dialysis and Transplant Association"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfh485"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5002776"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1016\/j.lpm.2014.03.032"}],"container-title":["Case Reports in Nephrology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/crin\/2016\/1971465.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crin\/2016\/1971465.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crin\/2016\/1971465.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2016,8,18]],"date-time":"2016-08-18T09:51:16Z","timestamp":1471513876000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/crin\/2016\/1971465\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":14,"alternative-id":["1971465","1971465"],"URL":"https:\/\/doi.org\/10.1155\/2016\/1971465","relation":{},"ISSN":["2090-6641","2090-665X"],"issn-type":[{"value":"2090-6641","type":"print"},{"value":"2090-665X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016]]}}}