{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T21:28:34Z","timestamp":1790458114085,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Ophthalmology"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p><jats:italic>Purpose<\/jats:italic>. To assess the clinical and morphological outcomes of topography-guided accelerated corneal cross-linking.<jats:italic> Design<\/jats:italic>. Retrospective case series.<jats:italic> Methods<\/jats:italic>. 21 eyes of 20 patients with progressive keratoconus were enrolled. All patients underwent accelerated cross-linking using an ultraviolet-A (UVA) exposure with an energy release varying from 7.2\u2009J\/cm<jats:sup>2<\/jats:sup> up to 15\u2009J\/cm<jats:sup>2<\/jats:sup>, according to the topographic corneal curvature. Uncorrected (UDVA) and corrected (CDVA) distance visual acuity, topography, in vivo confocal microscopy (IVCM), and anterior segment optic coherence tomography (AS-OCT) were evaluated preoperatively and at the 1, 3, 6, and 12 months postoperatively.<jats:italic> Results<\/jats:italic>. 12 months after surgery UDVA and CDVA did not significantly vary from preoperative values. The average topographic astigmatism decreased from <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mo>-<\/mml:mo><mml:mn fontstyle=\"italic\">4.61<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn fontstyle=\"italic\">0.74<\/mml:mn><\/mml:math> diopters (D) to <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mo>-<\/mml:mo><mml:mn fontstyle=\"italic\">3.20<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn fontstyle=\"italic\">0.81<\/mml:mn><\/mml:math>\u2009D and coma aberration improved from 0.95 \u00b1 0.03\u2009<jats:italic>\u03bc<\/jats:italic>m to 0.88 \u00b1 0.04\u2009<jats:italic>\u03bc<\/jats:italic>m after surgery. AS-OCT and IVCM documented differential effects on the treated areas using different energies doses. The depths of demarcation line and keratocyte apoptosis were assessed.<jats:italic> Conclusions<\/jats:italic>. Preliminary results show correspondence between the energy dose applied and the microstructural stromal changes induced by the cross-linking at various depths in different areas of treated cornea. One year after surgery a significant reduction in the topographic astigmatism and comatic aberration was detected. None of the patients developed significant complications.<\/jats:p>","DOI":"10.1155\/2016\/2031031","type":"journal-article","created":{"date-parts":[[2016,11,28]],"date-time":"2016-11-28T16:23:05Z","timestamp":1480350185000},"page":"1-10","source":"Crossref","is-referenced-by-count":40,"title":["Accelerated Corneal Collagen Cross-Linking Using Topography-Guided UV-A Energy Emission: Preliminary Clinical and Morphological Outcomes"],"prefix":"10.1155","volume":"2016","author":[{"given":"Cosimo","family":"Mazzotta","sequence":"first","affiliation":[{"name":"Siena Int. 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