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Poly(<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mrow><mml:mi>\u03f5<\/mml:mi><\/mml:mrow><\/mml:math>-caprolactone) (PCL),<jats:italic>\u03b2<\/jats:italic>-tricalcium phosphate (TCP), and poly(lactic-co-glycolic acid) (PLGA) are widely used as synthetic materials for tissue engineering. This study aimed to investigate the bone-healing capacity of PCL\/PLGA\/duck beak scaffold in critical bone defects and the oxidative stress status of the graft site in a rabbit model. The<jats:italic>in vivo<\/jats:italic>performance of 48 healthy New Zealand White rabbits, weighing between 2.5 and 3.5\u2009kg, was evaluated. The rabbits were assigned to the following groups: group 1 (control), group 2 (PCL\/PLGA hybrid scaffolds), group 3 (PCL\/PLGA\/TCP hybrid scaffolds), and group 4 (PCL\/PLGA\/DB hybrid scaffolds). A 5 mm critical defect was induced in the diaphysis of the left radius. X-ray, micro-CT, and histological analyses were conducted at (time 0) 4, 8, and 12 weeks after implantation. Furthermore, bone formation markers (bone-specific alkaline phosphatase, carboxyterminal propeptide of type I procollagen, and osteocalcin) were measured and oxidative stress status was determined. X-ray, micro-CT, biochemistry, and histological analyses revealed that the PCL\/PLGA\/duck beak scaffold promotes new bone formation in rabbit radius by inducing repair, suggesting that it could be a good option for the treatment of fracture.<\/jats:p>","DOI":"10.1155\/2016\/2136215","type":"journal-article","created":{"date-parts":[[2016,3,3]],"date-time":"2016-03-03T21:03:06Z","timestamp":1457038986000},"page":"1-10","source":"Crossref","is-referenced-by-count":14,"title":["Bone-Healing Capacity of PCL\/PLGA\/Duck Beak Scaffold in Critical Bone Defects in a Rabbit Model"],"prefix":"10.1155","volume":"2016","author":[{"given":"Jae Yeon","family":"Lee","sequence":"first","affiliation":[{"name":"College of Veterinary Medicine, Chungbuk National University, Cheongju 362-763, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soo Jin","family":"Son","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Chungbuk National University, 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