{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T06:50:15Z","timestamp":1772261415561,"version":"3.50.1"},"reference-count":57,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,7,25]],"date-time":"2016-07-25T00:00:00Z","timestamp":1469404800000},"content-version":"vor","delay-in-days":206,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81371485"],"award-info":[{"award-number":["81371485"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005225","name":"Construct Program of the Key Discipline in Hunan Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005225","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oxidative Medicine and Cellular Longevity"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:p>Chronic unpredictable mild stress (CUMS) induces hippocampal oxidative stress. H<jats:sub>2<\/jats:sub>S functions as a neuroprotectant against oxidative stress in brain. We have previously shown the upregulatory effect of H<jats:sub>2<\/jats:sub>S on BDNF protein expression in the hippocampus of rats. Therefore, we hypothesized that H<jats:sub>2<\/jats:sub>S prevents CUMS\u2010generated oxidative stress by upregulation of BDNF\u2010TrkB pathway. We showed that NaHS (0.03 or 0.1\u2009mmol\/kg\/day) ameliorates the level of hippocampal oxidative stress, including reduced levels of malondialdehyde (MDA) and 4\u2010hydroxy\u20102\u2010trans\u2010nonenal (4\u2010HNE), as well as increased level of glutathione (GSH) and activity of superoxide dismutase (SOD) in the hippocampus of CUMS\u2010treated rats. We also found that H<jats:sub>2<\/jats:sub>S upregulated the level of BDNF and p\u2010TrkB protein in the hippocampus of CUMS rats. Furthermore, inhibition of BDNF signaling by K252a, an inhibitor of the BDNF receptor TrkB, blocked the antioxidant effects of H<jats:sub>2<\/jats:sub>S on CUMS\u2010induced hippocampal oxidative stress. These results reveal the inhibitory role of H<jats:sub>2<\/jats:sub>S in CUMS\u2010induced hippocampal oxidative stress, which is through upregulation of BDNF\/TrkB pathway.<\/jats:p>","DOI":"10.1155\/2016\/2153745","type":"journal-article","created":{"date-parts":[[2016,7,25]],"date-time":"2016-07-25T21:00:57Z","timestamp":1469480457000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":52,"title":["Hydrogen Sulfide Protects against Chronic Unpredictable Mild Stress\u2010Induced Oxidative Stress in Hippocampus by Upregulation of BDNF\u2010TrkB Pathway"],"prefix":"10.1155","volume":"2016","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0989-0797","authenticated-orcid":false,"given":"Min","family":"Hu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Zou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun-Yan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1008-6237","authenticated-orcid":false,"given":"Xi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui-Ying","family":"Tan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hai-Ying","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong-Feng","family":"Gu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3518-9275","authenticated-orcid":false,"given":"Xiao-Qing","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,7,25]]},"reference":[{"key":"e_1_2_8_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0079-6123(08)62128-7"},{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1126\/stke.2252004re5"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(99)00009-8"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2006.02.013"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-5618.2002.01144.x"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2011.11.009"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-011-0486-2"},{"key":"e_1_2_8_8_2","first-page":"4","article-title":"Hydrogen sulfide (H2S)\u2014the third gas of interest for pharmacologists","volume":"59","author":"Lowicka E.","year":"2007","journal-title":"Pharmacological Reports"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2009.2938"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.02-0211hyp"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.16-03-01066.1996"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1999.1915"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.03-1052fje"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/glia.20362"},{"key":"e_1_2_8_15_2","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2008.2282"},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.04-1815fje"},{"key":"e_1_2_8_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12272-011-1220-y"},{"key":"e_1_2_8_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/abbs\/gmv009"},{"key":"e_1_2_8_19_2","doi-asserted-by":"publisher","DOI":"10.1080\/08977190410001723308"},{"key":"e_1_2_8_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9861(19970203)378:1<135::AID-CNE8>3.0.CO;2-5"},{"key":"e_1_2_8_21_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.15-03-01768.1995"},{"key":"e_1_2_8_22_2","doi-asserted-by":"publisher","DOI":"10.1503\/jpn.130169"},{"key":"e_1_2_8_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/acer.12104"},{"key":"e_1_2_8_24_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0119478"},{"key":"e_1_2_8_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2009.07.002"},{"key":"e_1_2_8_26_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00181937"},{"key":"e_1_2_8_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1734-1140(11)70719-8"},{"key":"e_1_2_8_28_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2010.01119.x"},{"key":"e_1_2_8_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2011.02.016"},{"key":"e_1_2_8_30_2","doi-asserted-by":"publisher","DOI":"10.3109\/10253891003667862"},{"key":"e_1_2_8_31_2","first-page":"515","article-title":"Effect of fluoxetine and resveratrol on testicular functions and oxidative stress in a rat model of chronic mild stress-induced depression","volume":"66","author":"Sakr H. F.","year":"2015","journal-title":"Journal of Physiology and Pharmacology"},{"key":"e_1_2_8_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2015.09.031"},{"key":"e_1_2_8_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2013.01.020"},{"key":"e_1_2_8_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2014.12.048"},{"key":"e_1_2_8_35_2","doi-asserted-by":"publisher","DOI":"10.4103\/0253-7613.129316"},{"key":"e_1_2_8_36_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-016-9701-0"},{"key":"e_1_2_8_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2015.11.016"},{"key":"e_1_2_8_38_2","doi-asserted-by":"publisher","DOI":"10.1179\/135100003225003393"},{"key":"e_1_2_8_39_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-006-9258-9"},{"key":"e_1_2_8_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2010.05.004"},{"key":"e_1_2_8_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0165-0327(00)00199-3"},{"key":"e_1_2_8_42_2","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2009.2882"},{"key":"e_1_2_8_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2012.10.046"},{"key":"e_1_2_8_44_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12640-009-9099-9"},{"key":"e_1_2_8_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2004.11.110"},{"key":"e_1_2_8_46_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2004.02617.x"},{"key":"e_1_2_8_47_2","doi-asserted-by":"publisher","DOI":"10.1097\/FBP.0b013e3283654258"},{"key":"e_1_2_8_48_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms141122558"},{"key":"e_1_2_8_49_2","first-page":"167","article-title":"The neuroprotective roles of BDNF in hypoxic ischemic brain injury","volume":"1","author":"Chen A.","year":"2013","journal-title":"Bioscience Reports"},{"key":"e_1_2_8_50_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cdd.4401662"},{"key":"e_1_2_8_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2009.01.015"},{"key":"e_1_2_8_52_2","doi-asserted-by":"publisher","DOI":"10.1038\/aps.2013.197"},{"key":"e_1_2_8_53_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-015-9357-1"},{"key":"e_1_2_8_54_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M113.543942"},{"key":"e_1_2_8_55_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi061853s"},{"key":"e_1_2_8_56_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.12-226415"},{"key":"e_1_2_8_57_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep14774"}],"container-title":["Oxidative Medicine and Cellular Longevity"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/omcl\/2016\/2153745.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/omcl\/2016\/2153745.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2016\/2153745","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,6]],"date-time":"2024-08-06T01:44:24Z","timestamp":1722908664000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2016\/2153745"}},"subtitle":[],"editor":[{"given":"Massimo","family":"Collino","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2016,1]]},"references-count":57,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,1]]}},"alternative-id":["10.1155\/2016\/2153745"],"URL":"https:\/\/doi.org\/10.1155\/2016\/2153745","archive":["Portico"],"relation":{},"ISSN":["1942-0900","1942-0994"],"issn-type":[{"value":"1942-0900","type":"print"},{"value":"1942-0994","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,1]]},"assertion":[{"value":"2016-04-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-06-15","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-07-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2153745"}}