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The free complex and the corresponding conjugate with<jats:bold>DS<\/jats:bold>were tested on two standard human tumor cell lines, namely, ovarian A2780 and colon HCT 116, and on several malignant pleural mesothelioma cell lines (namely, epithelioid BR95, mixed\/biphasic MG06, sarcomatoid MM98, and sarcomatoid cisplatin-resistant MM98R). The<jats:italic>in vitro<\/jats:italic>results suggest that the conjugate releases the active metabolite phenanthriplatin with a biphasic fashion. 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