{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,5,23]],"date-time":"2023-05-23T18:56:13Z","timestamp":1684868173761},"reference-count":11,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Canadian Journal of Infectious Diseases and Medical Microbiology"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p>Tumour necrosis factor alpha inhibitors, such as infliximab, and other biologic agents are associated with increased risk of opportunistic infection, including tuberculosis. Tuberculosis infections associated with infliximab tend to present atypically and can be difficult to diagnose, as they are more likely to manifest as extrapulmonary or disseminated disease. The authors report a case involving a 29-year-old male patient who died following 16 days of treatment for undifferentiated sepsis and who was found on autopsy to have widespread disseminated tuberculosis. Prior to the onset of illness, the patient had received infliximab for the treatment of Crohn\u2019s disease. Following discussion of the case, the authors review the definition of adverse events, provide a root cause analysis of the cognitive errors and breakdowns in the health care system that contributed to the reported outcome, and identify opportunities to address these breakdowns and improve patient safety measures for future cases.<\/jats:p>","DOI":"10.1155\/2016\/2478924","type":"journal-article","created":{"date-parts":[[2016,3,30]],"date-time":"2016-03-30T23:44:02Z","timestamp":1459381442000},"page":"1-6","source":"Crossref","is-referenced-by-count":2,"title":["Death of a 29-Year-Old Male from Undifferentiated Sepsis"],"prefix":"10.1155","volume":"2016","author":[{"given":"Kathryn A.","family":"Trebuss","sequence":"first","affiliation":[{"name":"Queen\u2019s University, Kingston, ON, Canada K7L 3N6"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samantha","family":"Buttemer","sequence":"additional","affiliation":[{"name":"Queen\u2019s University, Kingston, ON, Canada K7L 3N6"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey S.","family":"Wilkinson","sequence":"additional","affiliation":[{"name":"Queen\u2019s University, Kingston, ON, Canada K7L 3N6"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josie","family":"Xu","sequence":"additional","affiliation":[{"name":"University of Toronto, Toronto, ON, Canada M5S 1A8"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John P.","family":"Rossiter","sequence":"additional","affiliation":[{"name":"Department of Pathology and Molecular Medicine, Queen\u2019s University and Kingston General Hospital, Kingston, ON, Canada K7L 3N6"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kieran M.","family":"Moore","sequence":"additional","affiliation":[{"name":"Department of Family Medicine and Emergency Medicine, Queen\u2019s University, Kingston, ON, Canada K7L 3N6"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"98","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-007-0934-2"},{"issue":"9","key":"2","first-page":"1153","volume":"168","year":"2003","journal-title":"Canadian Medical Association Journal"},{"key":"3","volume-title":"Remicade","year":"2007"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa011110"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1517\/14740338.2015.1009036"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1086\/429998"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1016\/s1473-3099(03)00545-0"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.1040498"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cit248"},{"key":"10","volume":"130","year":"2000"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1056\/nejmp1303712"}],"container-title":["Canadian Journal of Infectious Diseases and Medical Microbiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/cjidmm\/2016\/2478924.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/cjidmm\/2016\/2478924.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/cjidmm\/2016\/2478924.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2016,8,18]],"date-time":"2016-08-18T15:47:52Z","timestamp":1471535272000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/cjidmm\/2016\/2478924\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":11,"alternative-id":["2478924","2478924"],"URL":"https:\/\/doi.org\/10.1155\/2016\/2478924","relation":{},"ISSN":["1712-9532","1918-1493"],"issn-type":[{"value":"1712-9532","type":"print"},{"value":"1918-1493","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016]]}}}