{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T12:41:10Z","timestamp":1773060070101,"version":"3.50.1"},"reference-count":15,"publisher":"Wiley","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Canadian Journal of Gastroenterology and Hepatology"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p><jats:italic>Objectives.<\/jats:italic>To determine the relationship between fecal calprotectin (FCAL) and imaging studies and other biochemical inflammatory markers and the impact of FCAL measurements on decision-making in IBD patient management in usual clinical practice.<jats:italic>Methods.<\/jats:italic>240 persons with IBD were enrolled. The correlation between FCAL values and other markers for disease activity such as serum albumin (alb), hemoglobin (Hg), and C-reactive protein (CRP) and diagnostic imaging or colonoscopy was examined. FCAL \u2265 250\u2009mcg\/g of stool was considered a positive result indicating active IBD.<jats:italic>Results.<\/jats:italic>183 stool samples (76.3%) were returned. The return rate in the pediatric and adult cohorts was 91% (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>n<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">82<\/mml:mn><\/mml:math>) and 67.3% (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>n<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">101<\/mml:mn><\/mml:math>), respectively (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn fontstyle=\"italic\">0.0001<\/mml:mn><\/mml:math>). Positive FCAL was associated with colonoscopy findings of active IBD (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn fontstyle=\"italic\">0.05<\/mml:mn><\/mml:math>), low albumin (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn fontstyle=\"italic\">0.05<\/mml:mn><\/mml:math>), anemia (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn fontstyle=\"italic\">0.01<\/mml:mn><\/mml:math>), and elevated CRP (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M7\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn fontstyle=\"italic\">0.01<\/mml:mn><\/mml:math>). There was no significant difference for FCAL results by outcomes on small bowel evaluation among the 21 persons with small bowel CD. Most persons (87.5%) with normal FCAL and no change in therapy remained in remission during subsequent 3 months.<jats:italic>Conclusions.<\/jats:italic>FCAL is a useful marker of disease activity and a valuable tool in managing persons with IBD in clinical practice. Clinicians have to be cautious in interpreting FCAL results in small bowel CD.<\/jats:p>","DOI":"10.1155\/2016\/2483261","type":"journal-article","created":{"date-parts":[[2016,9,28]],"date-time":"2016-09-28T17:08:25Z","timestamp":1475082505000},"page":"1-6","source":"Crossref","is-referenced-by-count":37,"title":["The Utility of Fecal Calprotectin in the Real-World Clinical Care of Patients with Inflammatory Bowel Disease"],"prefix":"10.1155","volume":"2016","author":[{"given":"Esmail","family":"Abej","sequence":"first","affiliation":[{"name":"Section of Gastroenterology, Department of Internal Medicine, Winnipeg, MB, Canada"},{"name":"University of Manitoba and the University of Manitoba IBD Clinical and Research Centre, Winnipeg, MB, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6417-7583","authenticated-orcid":true,"given":"Wael","family":"El-Matary","sequence":"additional","affiliation":[{"name":"University of Manitoba and the University of Manitoba IBD Clinical and Research Centre, Winnipeg, MB, Canada"},{"name":"Pediatric Gastroenterology, Department of Pediatrics and Child Health, Winnipeg, MB, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9354-2356","authenticated-orcid":true,"given":"Harminder","family":"Singh","sequence":"additional","affiliation":[{"name":"Section of Gastroenterology, Department of Internal Medicine, Winnipeg, MB, Canada"},{"name":"University of Manitoba and the University of Manitoba IBD Clinical and Research Centre, Winnipeg, MB, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8041-3574","authenticated-orcid":true,"given":"Charles N.","family":"Bernstein","sequence":"additional","affiliation":[{"name":"Section of Gastroenterology, Department of Internal Medicine, Winnipeg, MB, Canada"},{"name":"University of Manitoba and the University of Manitoba IBD Clinical and Research Centre, Winnipeg, MB, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2011.06.054"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/737349"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2015.233"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1136\/gut.47.4.506"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.3310\/hta17550"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.22917"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2009.545"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.20986"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2007.01126.x"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.c3369"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.22861"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1097\/mib.0000000000000057"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1016\/j.acra.2014.05.002"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1097\/MIB.0000000000000404"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-013-3010-z"}],"container-title":["Canadian Journal of Gastroenterology and Hepatology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/cjgh\/2016\/2483261.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/cjgh\/2016\/2483261.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/cjgh\/2016\/2483261.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2016,9,28]],"date-time":"2016-09-28T17:08:25Z","timestamp":1475082505000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/cjgh\/2016\/2483261\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":15,"alternative-id":["2483261","2483261"],"URL":"https:\/\/doi.org\/10.1155\/2016\/2483261","relation":{},"ISSN":["2291-2789","2291-2797"],"issn-type":[{"value":"2291-2789","type":"print"},{"value":"2291-2797","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016]]}}}