{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T16:21:33Z","timestamp":1751473293999},"reference-count":19,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Rajiv Gandhi National Fellowship Scheme"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Advances in Pharmacological Sciences"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p><jats:italic>Objective<\/jats:italic>. The whole plant of<jats:italic>Houttuynia cordata<\/jats:italic>has been reported to have potent antihyperglycemic activity. Therefore, the present study was undertaken to investigate the glucose utilization capacity of bioactive fractions of ethanol extract of<jats:italic>Houttuynia cordata<\/jats:italic>(HC) in isolated rat hemidiaphragm.<jats:italic>Methods<\/jats:italic>. All the fractions, that is, aqueous (AQ), hexane (HEX), chloroform (CHL), and ethyl acetate (EA), obtained from ethanol extract of<jats:italic>H. cordata<\/jats:italic>were subjected to phytochemical standardization use in quercetin as a marker with the help of HPTLC. Further, glucose utilization capacity by rat hemidiaphragm was evaluated in 12 different sets of<jats:italic>in vitro<\/jats:italic>experiments. In the study, different fractions from<jats:italic>H. cordata<\/jats:italic>as mentioned above were evaluated, where insulin was used as standard and quercetin as a biological standard.<jats:italic>Results<\/jats:italic>. Among all the tested fractions, AQ and EA significantly increased glucose uptake by isolated rat hemidiaphragm compared to negative control. Moreover, AQ fractions enhanced the uptake of glucose significantly (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>p<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn fontstyle=\"italic\">0.05<\/mml:mn><\/mml:math>) and was found to be more effective than insulin.<jats:italic>Conclusions<\/jats:italic>. The augmentation in glucose uptake by hemidiaphragm in presence of AQ and EA fractions may be attributed to the presence of quercetin, which was found to be 7.1 and 3.2% w\/w, respectively, in both the fractions.<\/jats:p>","DOI":"10.1155\/2016\/2573604","type":"journal-article","created":{"date-parts":[[2016,1,26]],"date-time":"2016-01-26T21:01:00Z","timestamp":1453842060000},"page":"1-5","source":"Crossref","is-referenced-by-count":5,"title":["<i>In Vitro<\/i>Study on Glucose Utilization Capacity of Bioactive Fractions of<i>Houttuynia cordata<\/i>in Isolated Rat Hemidiaphragm and Its Major Phytoconstituent"],"prefix":"10.1155","volume":"2016","author":[{"given":"Manish","family":"Kumar","sequence":"first","affiliation":[{"name":"Pharmacognosy Research Laboratory, Department of Pharmaceutics, Indian Institute of Technology (Banaras Hindu University), Varanasi 221005, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satyendra K.","family":"Prasad","sequence":"additional","affiliation":[{"name":"Pharmacognosy Research Laboratory, Department of Pharmaceutics, Indian Institute of Technology (Banaras Hindu University), Varanasi 221005, India"},{"name":"Department of Pharmaceutical Sciences, R. 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Nagpur University, Nagpur 440033, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siva","family":"Hemalatha","sequence":"additional","affiliation":[{"name":"Pharmacognosy Research Laboratory, Department of Pharmaceutics, Indian Institute of Technology (Banaras Hindu University), Varanasi 221005, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"98","reference":[{"issue":"1","key":"2","first-page":"30","volume":"83","year":"2002","journal-title":"Current Science"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/s0378-8741(02)00059-4"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.3164\/jcbn.40.163"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.4103\/0973-7847.125525"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2005.09.012"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-961554"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/809438"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1016\/s2221-6189(14)60015-9"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2008.03.002"},{"issue":"5","key":"11","first-page":"526","volume":"4","year":"2006","journal-title":"Zhong Xi Yi Jie He Xue Bao"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.200700360"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2009.07.026"},{"key":"14","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.cbi.2009.05.010","volume":"181","year":"2009","journal-title":"Chemico-Biological Interactions"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2006.09.039"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-7743(00)35027-8"},{"issue":"2","key":"17","first-page":"20","volume":"21","year":"2005","journal-title":"Indian Journal of Natural products"},{"key":"18","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S2221-6189(13)60091-8","volume":"2","year":"2013","journal-title":"Journal of Acute Disease"},{"issue":"14","key":"19","doi-asserted-by":"crossref","first-page":"7090","DOI":"10.1016\/S0021-9258(19)68926-X","volume":"256","year":"1981","journal-title":"The Journal of Biological Chemistry"},{"issue":"2","key":"20","first-page":"251","volume":"4","year":"2012","journal-title":"International Journal of Pharmacy and Pharmaceutical Sciences"}],"container-title":["Advances in Pharmacological Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/aps\/2016\/2573604.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/aps\/2016\/2573604.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/aps\/2016\/2573604.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,2]],"date-time":"2022-06-02T13:29:35Z","timestamp":1654176575000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/aps\/2016\/2573604\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":19,"alternative-id":["2573604","2573604"],"URL":"https:\/\/doi.org\/10.1155\/2016\/2573604","relation":{},"ISSN":["1687-6334","1687-6342"],"issn-type":[{"value":"1687-6334","type":"print"},{"value":"1687-6342","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016]]}}}