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In the lack of a valid alternative approach, current treatments focus on suppression of gastric acid secretion by the use of proton pump inhibitors (PPIs), but people with GER have a significantly lower response rate to therapy. We designed a randomized double\u2010blinded controlled clinical study to evaluate the efficacy and the safety of a formulation based on sodium alginate\/bicarbonate in combination with extracts obtained from <jats:italic>Opuntia ficus-indica<\/jats:italic> and <jats:italic>Olea europaea<\/jats:italic> associated with polyphenols (Mucosave\u00ae; <jats:italic>verum<\/jats:italic>), on GER\u2010related symptoms. Male\/female 118 (intention to treat) subjects with moderate GER and having at least 2 to 6 days of GER episodes\/week were treated with <jats:italic>verum<\/jats:italic> (6\u2009g\/day) or placebo for two months. The questionnaires Gastroesophageal Reflux Disease\u2010Health\u2010Related Quality of Life (GERD\u2010HRQoL) and Gastroesophageal Reflux Disease Symptom Assessment Scale (GSAS) were self\u2010administered by participants before the treatment and at the end of the treatment. <jats:italic>Verum<\/jats:italic> produced statistically significant reduction of GERD\u2010HRQoL and GSAS scores, \u221256.5% and \u221259.1%, respectively, in comparison to placebo. Heartburn and acid regurgitation episodes for week were significantly reduced by <jats:italic>verum<\/jats:italic> (<jats:italic>p<\/jats:italic> &lt; 0.01). Results indicate that Mucosave formulation provides an effective and well\u2010tolerated treatment for reducing the frequency and intensity of symptoms associated with gastroesophageal reflux.<\/jats:p>","DOI":"10.1155\/2016\/2581461","type":"journal-article","created":{"date-parts":[[2016,10,12]],"date-time":"2016-10-12T21:01:13Z","timestamp":1476306073000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Efficacy and Safety of a Natural Remedy for the Treatment of Gastroesophageal Reflux: A Double\u2010Blinded Randomized\u2010Controlled 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