{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T04:31:27Z","timestamp":1759638687392,"version":"3.37.3"},"reference-count":22,"publisher":"Wiley","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007055","name":"Third Military Medical University","doi-asserted-by":"publisher","award":["2015YLC10","2011XLC43"],"award-info":[{"award-number":["2015YLC10","2011XLC43"]}],"id":[{"id":"10.13039\/501100007055","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007055","name":"Third Military Medical University","doi-asserted-by":"publisher","award":["2015YLC10","2011XLC43"],"award-info":[{"award-number":["2015YLC10","2011XLC43"]}],"id":[{"id":"10.13039\/501100007055","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2016]]},"abstract":"<jats:p><jats:italic>Aims<\/jats:italic>. To detect anatomical and intrinsic histopathological features of the ascending aorta and left ventricular (LV) myocardium and evaluate right ventricular (RV) function in fetuses with hypoplastic left heart syndrome (HLHS).<jats:italic>Methods<\/jats:italic>. Twenty-five fetuses diagnosed with HLHS were followed up in the antenatal and postpartum periods. 12 necropsy heart specimens were analyzed for morphological and histological changes.<jats:italic>Results<\/jats:italic>. Prenatal echocardiography and pathologic anatomy displayed the typical characteristics of HLHS as a severe underdevelopment of the LV in the form of mitral stenosis or atresia or as aortic atresia or stenosis, with a decreased ratio of aortic diameter to pulmonary artery diameter (median of 0.49 with a range of 0.24 to 0.69,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>p<\/mml:mi><mml:mo>\u2264<\/mml:mo><mml:mn fontstyle=\"italic\">0.001<\/mml:mn><\/mml:math>) and a higher ratio of RV diameter to LV diameter (median of 2.44 with a range of 1.33 to 6.25,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>p<\/mml:mi><mml:mo>\u2264<\/mml:mo><mml:mn fontstyle=\"italic\">0.001<\/mml:mn><\/mml:math>). The RV volume, stroke volume, and cardiac output in HLHS fetuses were increased compared with the gestational age-matched normal controls (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>p<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn fontstyle=\"italic\">0.01<\/mml:mn><\/mml:math>). Histological changes in the 12 HLHS specimens included LV myocardial fibrosis, aortic elastic fragmentation, and fibrosis.<jats:italic>Conclusions<\/jats:italic>. In addition to severe anatomical deformity, distinct histological abnormalities in the LV myocardium and aortic wall were identified in the fetuses with HLHS. RV function damage may be potentially exists.<\/jats:p>","DOI":"10.1155\/2016\/2616729","type":"journal-article","created":{"date-parts":[[2016,2,15]],"date-time":"2016-02-15T16:01:59Z","timestamp":1455552119000},"page":"1-9","source":"Crossref","is-referenced-by-count":4,"title":["Assessment of Structural and Functional Abnormalities of the Myocardium and the Ascending Aorta in Fetus with Hypoplastic Left Heart Syndrome"],"prefix":"10.1155","volume":"2016","author":[{"given":"Yan","family":"Jiang","sequence":"first","affiliation":[{"name":"Department of Ultrasound, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yali","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinliang","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Pathology, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongmei","family":"Xia","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"issue":"1","key":"1","first-page":"61","volume":"1","year":"1952","journal-title":"Laboratory Investigation"},{"issue":"4","key":"2","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1016\/S0031-3955(16)30727-1","volume":"5","year":"1958","journal-title":"Pediatric Clinics of North America"},{"doi-asserted-by":"publisher","key":"3","DOI":"10.1161\/circulationaha.109.870246"},{"doi-asserted-by":"publisher","key":"4","DOI":"10.1016\/j.jacc.2010.08.636"},{"doi-asserted-by":"publisher","key":"5","DOI":"10.1016\/j.jacc.2011.09.022"},{"doi-asserted-by":"publisher","key":"6","DOI":"10.1016\/j.amjcard.2010.08.022"},{"doi-asserted-by":"publisher","key":"7","DOI":"10.1016\/j.athoracsur.2008.10.073"},{"doi-asserted-by":"publisher","key":"8","DOI":"10.1046\/j.1469-0705.1992.02030175.x"},{"issue":"5","key":"9","first-page":"475","volume":"44","year":"1996","journal-title":"Anales Espa\u00f1oles de Pediatr\u00eda"},{"doi-asserted-by":"publisher","key":"10","DOI":"10.1002\/uog.7674"},{"doi-asserted-by":"publisher","key":"11","DOI":"10.1161\/01.cir.0000128690.35860.c5"},{"doi-asserted-by":"publisher","key":"12","DOI":"10.1161\/circulationaha.109.848994"},{"doi-asserted-by":"publisher","key":"13","DOI":"10.1016\/0002-9149(73)90810-2"},{"doi-asserted-by":"publisher","key":"14","DOI":"10.1016\/j.jacc.2011.04.046"},{"doi-asserted-by":"publisher","key":"15","DOI":"10.1203\/00006450-200007000-00010"},{"doi-asserted-by":"publisher","key":"16","DOI":"10.1002\/ajmg.c.31367"},{"doi-asserted-by":"publisher","key":"17","DOI":"10.4238\/2013.october.30.9"},{"doi-asserted-by":"publisher","key":"18","DOI":"10.1016\/j.echo.2011.09.019"},{"doi-asserted-by":"publisher","key":"19","DOI":"10.1016\/j.echo.2007.04.028"},{"doi-asserted-by":"publisher","key":"20","DOI":"10.1016\/j.amjcard.2005.05.063"},{"doi-asserted-by":"publisher","key":"21","DOI":"10.1016\/j.amjcard.2005.07.066"},{"doi-asserted-by":"publisher","key":"22","DOI":"10.1016\/j.echo.2013.02.001"}],"container-title":["BioMed Research International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2016\/2616729.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2016\/2616729.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2016\/2616729.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,24]],"date-time":"2017-06-24T01:59:15Z","timestamp":1498269555000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/bmri\/2016\/2616729\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":22,"alternative-id":["2616729","2616729"],"URL":"https:\/\/doi.org\/10.1155\/2016\/2616729","relation":{},"ISSN":["2314-6133","2314-6141"],"issn-type":[{"type":"print","value":"2314-6133"},{"type":"electronic","value":"2314-6141"}],"subject":[],"published":{"date-parts":[[2016]]}}}